iPTMnet Report for P10828 (THRB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P10828 / THB_HUMAN
Protein Name Thyroid hormone receptor beta
Gene Name Name: THRB
Synonyms:ERBA2,NR1A2,THR1;
Organism Homo sapiens (Human)

PRO ID PR:P10828
DAG View
PRO Name thyroid hormone receptor beta (human)
Definition A thyroid hormone receptor beta that is encoded in the genome of human.
Short Label hTHRB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P10828 (THRB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K50 Sumoylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S142 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   Signor 12809513
K146 Sumoylation PhosphoSitePlus
Y171 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
Y406 Phosphorylation P12931 (SRC) PhosphoSitePlus 25275301
K443 Sumoylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K50 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S55 L55 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S142 F142 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y406 C406 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y406 D406 Biomuta DOID:9256 / colorectal cancer [ cosmic ]