iPTMnet Report for P0CG48 (UBC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P0CG48 / UBC_HUMAN
Protein Name Polyubiquitin-C precursor
Gene Name Name: UBC
Organism Homo sapiens (Human)

PRO ID PR:P0CG48
DAG View
PRO Name polyubiquitin-C (human)
Definition A polyubiquitin-C that is encoded in the genome of human.
Short Label hUBC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P0CG48 (UBC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Acetylation PhosphoSitePlus
K6 Methylation PhosphoSitePlus
K6 Sumoylation PhosphoSitePlus
K6 Ubiquitination PhosphoSitePlus   UniProt 16443603
T7 Phosphorylation PhosphoSitePlus
K11 Acetylation PhosphoSitePlus
K11 Sumoylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus   UniProt 16443603, 16543144
T12 Phosphorylation PhosphoSitePlus
T14 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
T22 Phosphorylation PhosphoSitePlus
K27 Sumoylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus   UniProt 15466860
K29 Sumoylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus   UniProt 25752577, 16543144, 25752573, ...34239127
K33 Sumoylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus   UniProt 25752577
K48 Acetylation PhosphoSitePlus
K48 Sumoylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus   UniProt 16443603, 16543144
S57 Phosphorylation PhosphoSitePlus
Y59 Phosphorylation PhosphoSitePlus
K63 Methylation PhosphoSitePlus
K63 Sumoylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus   UniProt 16543144, 18719106
S65 Phosphorylation Q9BXM7 (PINK1) PhosphoSitePlus   Signor   UniProt 24784582, 24660806, 24751536, ...25527291
T66 Phosphorylation PhosphoSitePlus
R72 Methylation PhosphoSitePlus
K82 Acetylation PhosphoSitePlus
K82 Methylation PhosphoSitePlus
K82 Sumoylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
T83 Phosphorylation PhosphoSitePlus
K87 Acetylation PhosphoSitePlus
K87 Sumoylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
T90 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
T98 Phosphorylation PhosphoSitePlus
K103 Sumoylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K105 Sumoylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K109 Sumoylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K124 Acetylation PhosphoSitePlus
K124 Sumoylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
K139 Methylation PhosphoSitePlus
K139 Sumoylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
T142 Phosphorylation PhosphoSitePlus
R148 Methylation PhosphoSitePlus
K158 Acetylation PhosphoSitePlus
K158 Methylation PhosphoSitePlus
K158 Sumoylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
T159 Phosphorylation PhosphoSitePlus
K163 Acetylation PhosphoSitePlus
K163 Sumoylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
T174 Phosphorylation PhosphoSitePlus
K179 Sumoylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K200 Acetylation PhosphoSitePlus
K200 Sumoylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
Y211 Phosphorylation PhosphoSitePlus
K215 Methylation PhosphoSitePlus
K215 Sumoylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
T218 Phosphorylation PhosphoSitePlus
R224 Methylation PhosphoSitePlus
K234 Acetylation PhosphoSitePlus
K234 Methylation PhosphoSitePlus
K234 Sumoylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
T235 Phosphorylation PhosphoSitePlus
K239 Acetylation PhosphoSitePlus
K239 Sumoylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
T240 Phosphorylation PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
T250 Phosphorylation PhosphoSitePlus
K255 Sumoylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K257 Sumoylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
K261 Sumoylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K276 Acetylation PhosphoSitePlus
K276 Sumoylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
Y287 Phosphorylation PhosphoSitePlus
K291 Methylation PhosphoSitePlus
K291 Sumoylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
T294 Phosphorylation PhosphoSitePlus
R300 Methylation PhosphoSitePlus
K310 Acetylation PhosphoSitePlus
K310 Methylation PhosphoSitePlus
K310 Sumoylation PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
T311 Phosphorylation PhosphoSitePlus
K315 Acetylation PhosphoSitePlus
K315 Sumoylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
T316 Phosphorylation PhosphoSitePlus
T318 Phosphorylation PhosphoSitePlus
S324 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
K331 Sumoylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K333 Sumoylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
K337 Sumoylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K352 Acetylation PhosphoSitePlus
K352 Sumoylation PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
Y363 Phosphorylation PhosphoSitePlus
K367 Methylation PhosphoSitePlus
K367 Sumoylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
T370 Phosphorylation PhosphoSitePlus
R376 Methylation PhosphoSitePlus
K386 Acetylation PhosphoSitePlus
K386 Methylation PhosphoSitePlus
K386 Sumoylation PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
T387 Phosphorylation PhosphoSitePlus
K391 Acetylation PhosphoSitePlus
K391 Sumoylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus
T394 Phosphorylation PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus
T402 Phosphorylation PhosphoSitePlus
K407 Sumoylation PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K409 Sumoylation PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
K413 Sumoylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K428 Acetylation PhosphoSitePlus
K428 Sumoylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
Y439 Phosphorylation PhosphoSitePlus
K443 Methylation PhosphoSitePlus
K443 Sumoylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
T446 Phosphorylation PhosphoSitePlus
R452 Methylation PhosphoSitePlus
K462 Acetylation PhosphoSitePlus
K462 Methylation PhosphoSitePlus
K462 Sumoylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
T463 Phosphorylation PhosphoSitePlus
K467 Acetylation PhosphoSitePlus
K467 Sumoylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
T468 Phosphorylation PhosphoSitePlus
T470 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
T478 Phosphorylation PhosphoSitePlus
K483 Sumoylation PhosphoSitePlus
K483 Ubiquitination PhosphoSitePlus
K485 Sumoylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
K489 Sumoylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
K504 Acetylation PhosphoSitePlus
K504 Sumoylation PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus
Y515 Phosphorylation PhosphoSitePlus
K519 Methylation PhosphoSitePlus
K519 Sumoylation PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus
T522 Phosphorylation PhosphoSitePlus
R528 Methylation PhosphoSitePlus
K538 Acetylation PhosphoSitePlus
K538 Methylation PhosphoSitePlus
K538 Sumoylation PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
T539 Phosphorylation PhosphoSitePlus
K543 Acetylation PhosphoSitePlus
K543 Sumoylation PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
T544 Phosphorylation PhosphoSitePlus
T546 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
T554 Phosphorylation PhosphoSitePlus
K559 Sumoylation PhosphoSitePlus
K559 Ubiquitination PhosphoSitePlus
K561 Sumoylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K565 Sumoylation PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus
K580 Acetylation PhosphoSitePlus
K580 Sumoylation PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
Y591 Phosphorylation PhosphoSitePlus
K595 Methylation PhosphoSitePlus
K595 Sumoylation PhosphoSitePlus
K595 Ubiquitination PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
T598 Phosphorylation PhosphoSitePlus
R604 Methylation PhosphoSitePlus
K614 Acetylation PhosphoSitePlus
K614 Methylation PhosphoSitePlus
K614 Sumoylation PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
T615 Phosphorylation PhosphoSitePlus
K619 Acetylation PhosphoSitePlus
K619 Sumoylation PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
T620 Phosphorylation PhosphoSitePlus
T622 Phosphorylation PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
T630 Phosphorylation PhosphoSitePlus
K635 Sumoylation PhosphoSitePlus
K635 Ubiquitination PhosphoSitePlus
K637 Sumoylation PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
K641 Sumoylation PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
K656 Acetylation PhosphoSitePlus
K656 Sumoylation PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
Y667 Phosphorylation PhosphoSitePlus
K671 Methylation PhosphoSitePlus
K671 Sumoylation PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
T674 Phosphorylation PhosphoSitePlus
R680 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K29 M29 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K33 T33 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K48 I48 Biomuta DOID:1324 / lung cancer [ icgc ]
T83 I83 Biomuta DOID:4159 / skin cancer [ cosmic ]
T88 I88 Biomuta DOID:1319 / brain cancer [ icgc ]
K103 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K105 N105 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R148 C148 Biomuta DOID:4159 / skin cancer [ cosmic ]
R148 H148 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
R148 L148 Biomuta DOID:1324 / lung cancer [ cosmic ]
T164 I164 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T166 I166 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T174 I174 Biomuta DOID:4159 / skin cancer [ cosmic ]
S209 F209 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R224 H224 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R224 G224 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K234 E234 Biomuta DOID:1324 / lung cancer [ cosmic ]
K234 M234 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K239 E239 Biomuta DOID:263 / kidney cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T240 A240 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K261 N261 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T326 I326 Biomuta [ cosmic ]
S361 C361 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K386 R386 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K391 E391 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ]
K391 N391 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T402 I402 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y439 D439 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R452 C452 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S476 R476 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y515 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y515 F515 Biomuta DOID:1324 / lung cancer [ cosmic ]
S552 R552 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K561 N561 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
K637 N637 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K637 T637 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K641 T641 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R680 C680 Biomuta DOID:10534 / stomach cancer [ cosmic ]