iPTMnet Report for P0C0S8 (H2AC17)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P0C0S8 / H2A1_HUMAN
Protein Name Histone H2A type 1
Gene Name Name: H2AC17
Synonyms:H2AFP,HIST1H2AG;Synonyms:H2AFC,HIST1H2AI;Synonyms:H2AFD,HIST1H2AK;Synonyms:H2AFI,HIST1H2AL;Synonyms:H2AFN,HIST1H2AM;
Organism Homo sapiens (Human)

PRO ID PR:P0C0S8
DAG View
PRO Name histone H2A type 1-G/I/K/L/M (human)
Definition A histone H2A type 1-G/I/K/L/M that is encoded in the genome of human.
Short Label hHIST1H2A[G/I/K/L/M]
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P0C0S8 (H2AC17) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 15823041, 16457589, 11709551
S2 Phosphorylation O75582 (RPS6KA5) phospho.ELM   PRO   Signor   UniProt 15010469, 11709551
K6 Acetylation PRO 17709392
K10 Acetylation PRO 18552846, 12937907
K14 Ubiquitination UniProt 22713238, 22980979
K16 Ubiquitination UniProt 22713238, 22980979
S19 Phosphorylation PhosphoSitePlus
T102 O-Glycosylation GlyGen 21896475, 23301498, 30444036
Q105 Methylation UniProt 24352239
K119 Acetylation PhosphoSitePlus
K119 Sumoylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PRO   UniProt 18400894, 16359901, 15386022, ...25470042, 16702407
T121 Phosphorylation O43683 (BUB1) , PR:O43683 (hBUB1) PRO   Signor   UniProt 19965387, 14667408, 11756469, ...24140421, 15078818


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044889 (hHIST1H2A[G/I/K/L/M]/InitMet-/Ac:1) acK6 PRO 17709392
PR:000044890 (hHIST1H2A[G/I/K/L/M]/InitMet-/Ubiq:1) ubK120 PRO 15386022, 18400894
PR:000044891 (hHIST1H2A[G/I/K/L/M]/InitMet-/Phos:1) pS2 PRO 15010469
PR:000044893 (hHIST1H2A[G/I/K/L/M]/InitMet-/Ac:2) acK10 PRO 12937907, 18552846
PR:000044898 (hHIST1H2A[G/I/K/L/M]/InitMet-/Phos:2) pT121 PR:O43683 (hBUB1) PRO 11756469, 14667408, 19965387


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 F2 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S2 C2 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K6 N6 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K16 N16 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K119 T119 Biomuta DOID:363 / uterine cancer [ icgc ]