iPTMnet Report P0C0S5 H2AZ1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P0C0S5 / H2AZ_HUMAN
Protein Name	Histone H2A.Z
Gene Name	Name: H2AZ1 Synonyms:H2AFZ;
Organism	Homo sapiens (Human)

PRO ID	PR:P0C0S5 DAG View
PRO Name	histone H2A.Z (human)
Definition	A histone H2A.Z that is encoded in the genome of human.
Short Label	hH2AZ1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P0C0S5 (H2AZ1) as Substrate

P0C0S5

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	K5	Acetylation		score3	UniProt	16319397, 31527837, 16627869
	K5	Methylation		score2	UniProt	23324626
	K8	Acetylation		score3	UniProt	16319397, 19608861, 31527837, ...16627869
	K8	Methylation		score2	UniProt	23324626
	K12	Acetylation		score3	UniProt	19608861, 31527837, 16627869
	K14	Acetylation		score3	UniProt	19608861, 31527837
	S43	O-Glycosylation		score3	GlyGen	21896475, 32522876, 22121020, ...25367160
	K121	Ubiquitination		score1	PhosphoSitePlus
	K122	Ubiquitination		score4	PRO UniProt	11835281, 17636032

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000045023 (hH2AFZ/InitMet-/Ubiq:1)	ubK122		PRO	17636032

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
K5	N5	Biomuta		DOID:3571 / liver cancer [ cosmic, icgc ]
K8	N8	Biomuta		DOID:1612 / breast cancer [ cosmic, icgc ]
S43	C43	Biomuta		DOID:9256 / colorectal cancer [ cosmic, icgc ]
S43	I43	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ]