iPTMnet Report for P09874 (PARP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P09874 / PARP1_HUMAN
Protein Name Poly [ADP-ribose] polymerase 1
Gene Name Name: PARP1
Synonyms:ADPRT;
Organism Homo sapiens (Human)

PRO ID PR:P09874
DAG View
PRO Name poly [ADP-ribose] polymerase 1 (human)
Definition A poly [ADP-ribose] polymerase 1 that is encoded in the genome of human.
Short Label hPARP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P09874 (PARP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S5 Phosphorylation PhosphoSitePlus
K7 Ubiquitination PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
K23 Methylation PhosphoSitePlus
C24 S-Nitrosylation dbSNO 26338901
S25 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
S41 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K59 Methylation PhosphoSitePlus
R65 Methylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
R78 Methylation PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
K97 Acetylation PhosphoSitePlus   UniProt 19608861
K97 Sumoylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K105 Acetylation PhosphoSitePlus   UniProt 19608861
K105 Sumoylation PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
Y117 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K131 Acetylation PhosphoSitePlus   UniProt 19608861
K131 Ubiquitination PhosphoSitePlus
K148 Acetylation PhosphoSitePlus
K148 Sumoylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
R156 Methylation PhosphoSitePlus
K165 Methylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
S177 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 23382195, 20068231
S177 Phosphorylation P54646 (PRKAA2) PhosphoSitePlus 23382195
S179 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 20068231
K182 Ubiquitination PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus   UniProt 23186163
T189 Phosphorylation PhosphoSitePlus
K192 Sumoylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K203 Sumoylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
K209 Methylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
K230 Acetylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K249 Acetylation PhosphoSitePlus
K249 Sumoylation PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K253 Acetylation PhosphoSitePlus
K254 Acetylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
K262 Acetylation PhosphoSitePlus
K262 Sumoylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
S274 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S277 Phosphorylation PhosphoSitePlus   UniProt 23186163
R282 Methylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K331 Sumoylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K337 Sumoylation PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus   UniProt 24275569
T368 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S372 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   Signor 18669648, 16627622
S372 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   Signor 16627622
T373 Phosphorylation PhosphoSitePlus   Signor 16627622
T373 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   Signor 16627622
S375 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
K400 Acetylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
K409 Sumoylation PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
K418 Acetylation PhosphoSitePlus
K418 Methylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
T420 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K433 Acetylation PhosphoSitePlus
K433 Sumoylation PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
S465 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 25069723, 20068231
K467 Sumoylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
K486 Sumoylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
K498 Acetylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus
K505 Acetylation PhosphoSitePlus
K508 Acetylation PhosphoSitePlus
K508 Methylation PhosphoSitePlus
K512 Sumoylation PhosphoSitePlus
K518 Acetylation PhosphoSitePlus
K518 Sumoylation PhosphoSitePlus
S519 Phosphorylation IEDB   PhosphoSitePlus 35494241
K521 Acetylation PhosphoSitePlus
K524 Acetylation PhosphoSitePlus
K528 Sumoylation PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
K548 Acetylation PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
K571 Ubiquitination PhosphoSitePlus
K579 Acetylation PhosphoSitePlus
K579 Methylation PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
R582 Methylation PhosphoSitePlus
T594 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 35460603
K600 Acetylation PhosphoSitePlus   UniProt 19608861
K600 Sumoylation PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
K621 Acetylation PhosphoSitePlus   UniProt 19608861
K621 Ubiquitination PhosphoSitePlus
K629 Acetylation PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
K633 Acetylation PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
K637 Acetylation PhosphoSitePlus
K637 Sumoylation PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
Y645 Phosphorylation PhosphoSitePlus
K653 Sumoylation PhosphoSitePlus
K653 Ubiquitination PhosphoSitePlus
K654 Acetylation PhosphoSitePlus
K654 Methylation PhosphoSitePlus
K654 Sumoylation PhosphoSitePlus
K654 Ubiquitination PhosphoSitePlus
T661 Phosphorylation PhosphoSitePlus
K662 Ubiquitination PhosphoSitePlus
K664 Ubiquitination PhosphoSitePlus
K667 Ubiquitination PhosphoSitePlus
K674 Methylation PhosphoSitePlus
S681 Phosphorylation PhosphoSitePlus
K683 Acetylation PhosphoSitePlus
Y689 Phosphorylation PhosphoSitePlus
K695 Ubiquitination PhosphoSitePlus
K700 Acetylation PhosphoSitePlus
K700 Ubiquitination PhosphoSitePlus
S702 Phosphorylation PhosphoSitePlus
S727 Phosphorylation PhosphoSitePlus
S733 Phosphorylation PhosphoSitePlus
Y737 Phosphorylation PhosphoSitePlus
T738 Phosphorylation PhosphoSitePlus
K748 Sumoylation PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus
K761 Sumoylation PhosphoSitePlus
Y775 Phosphorylation PhosphoSitePlus
R779 Methylation PhosphoSitePlus
S782 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 19691289, ...19690332, 19651622, 18669648, 21922195, 19415658, 20068231
S785 Phosphorylation PhosphoSitePlus   RLIMS-P 21922195
S786 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21922195, 23186163
K787 Ubiquitination PhosphoSitePlus
Y794 Phosphorylation PhosphoSitePlus
K796 Methylation PhosphoSitePlus
K796 Sumoylation PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
K802 Sumoylation PhosphoSitePlus
R806 Methylation PhosphoSitePlus
S808 Phosphorylation PhosphoSitePlus
R815 Methylation PhosphoSitePlus
K819 Ubiquitination PhosphoSitePlus
T824 Phosphorylation PhosphoSitePlus
Y829 Phosphorylation PhosphoSitePlus
K838 Ubiquitination PhosphoSitePlus
K852 Acetylation PhosphoSitePlus
K852 Ubiquitination PhosphoSitePlus
S864 Phosphorylation HPRD   PhosphoSitePlus 20068231
S874 Phosphorylation PhosphoSitePlus
R878 Methylation PhosphoSitePlus
Y896 Phosphorylation PhosphoSitePlus
Y907 Phosphorylation PhosphoSitePlus   RLIMS-P 26779812, 33520371
Y907 Phosphorylation P08581 (MET) PhosphoSitePlus 26779812
K940 Ubiquitination PhosphoSitePlus
K949 Acetylation PhosphoSitePlus
K949 Ubiquitination PhosphoSitePlus
Y992 Phosphorylation PhosphoSitePlus
K1010 Methylation PhosphoSitePlus
K1010 Ubiquitination PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O60566 (hBUB1B) Interaction PR:P09874 (hPARP1) PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
A2 G2 Biomuta DOID:1319 / brain cancer [ cosmic ]
S41 L41 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
K59 N59 Biomuta DOID:1324 / lung cancer [ cosmic ]
R65 W65 Biomuta DOID:1612 / breast cancer [ cosmic ]
R65 Q65 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R78 W78 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:1612 / breast cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
R78 Q78 Biomuta [ cosmic ]
R78 L78 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K105 E105 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R156 P156 Biomuta DOID:3571 / liver cancer [ cosmic ]
S177 N177 Biomuta DOID:3571 / liver cancer [ cosmic ]
K203 R203 Biomuta DOID:184 / bone cancer [ cosmic ]
K221 N221 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K254 N254 Biomuta DOID:1612 / breast cancer [ cosmic ]
S257 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
S274 F274 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R282 * Biomuta DOID:363 / uterine cancer [ cosmic ]
R282 Q282 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S364 F364 Biomuta DOID:4159 / skin cancer [ cosmic ]
T368 A368 Biomuta DOID:1612 / breast cancer [ cosmic ]
S375 L375 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K409 E409 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K418 E418 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T420 M420 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S455 F455 Biomuta DOID:1324 / lung cancer [ cosmic ]
K467 Q467 Biomuta DOID:1324 / lung cancer [ cosmic ]
S479 F479 Biomuta DOID:1319 / brain cancer [ cosmic ]
K498 E498 Biomuta DOID:363 / uterine cancer [ cosmic ]
S499 L499 Biomuta DOID:4159 / skin cancer [ cosmic ]
K508 T508 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K512 E512 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S519 A519 Biomuta DOID:1324 / lung cancer [ cosmic ]
K551 R551 Biomuta DOID:1324 / lung cancer [ cosmic ]
K579 R579 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T594 M594 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ]
S606 F606 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K629 E629 Biomuta DOID:4159 / skin cancer [ cosmic ]
K664 R664 Biomuta DOID:1324 / lung cancer [ cosmic ]
K667 E667 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T738 I738 Biomuta [ cosmic ]
S785 N785 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y794 * Biomuta DOID:263 / kidney cancer [ cosmic ]
K802 N802 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S808 T808 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S808 C808 Biomuta DOID:1319 / brain cancer [ cosmic ]
K819 E819 Biomuta DOID:1319 / brain cancer [ cosmic ]
S864 A864 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
R878 W878 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]