iPTMnet Report for P08833 (IGFBP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08833 / IBP1_HUMAN
Protein Name Insulin-like growth factor-binding protein 1 precursor
Gene Name Name: IGFBP1
Synonyms:IBP1;
Organism Homo sapiens (Human)

PRO ID PR:P08833
DAG View
PRO Name insulin-like growth factor-binding protein 1 (human)
Definition An insulin-like growth factor-binding protein 1 that is encoded in the genome of human.
Short Label hIGFBP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08833 (IGFBP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S45 Phosphorylation UniProt 26091039
S83 Phosphorylation PhosphoSitePlus
S108 Phosphorylation HPRD 7678248
S120 Phosphorylation PhosphoSitePlus   UniProt 19765076
S123 Phosphorylation PhosphoSitePlus   UniProt 19765076
S126 Phosphorylation P68400 (CSNK2A1) , P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19765076, 26733150, 24437487, ...7678248
T127 Phosphorylation PhosphoSitePlus
S144 Phosphorylation P68400 (CSNK2A1) , P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 26733150, 19765076, 24275569, ...7678248, 24437487
S156 Phosphorylation UniProt 26091039
T157 Phosphorylation UniProt 26091039
Y158 Phosphorylation UniProt 26091039
Y181 Phosphorylation PhosphoSitePlus
T193 Phosphorylation UniProt 26091039
S194 Phosphorylation P68400 (CSNK2A1) , P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 26733150, 19765076, 7678248, ...26091039, 24437487
S199 Phosphorylation PhosphoSitePlus   UniProt 26091039
S242 Phosphorylation UniProt 26091039


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S120 I120 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T127 M127 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
Y158 C158 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T193 S193 Biomuta DOID:4159 / skin cancer [ cosmic ]
S199 F199 Biomuta DOID:4159 / skin cancer [ cosmic ]