iPTMnet Report for P08758 (ANXA5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08758 / ANXA5_HUMAN
Protein Name Annexin A5
Gene Name Name: ANXA5
Synonyms:ANX5,ENX2,PP4;
Organism Homo sapiens (Human)

PRO ID PR:P08758
DAG View
PRO Name annexin A5 (human)
Definition An annexin A5 that is encoded in the genome of human.
Short Label hANXA5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08758 (ANXA5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
R6 Methylation PhosphoSitePlus
T10 Phosphorylation PhosphoSitePlus
R18 Methylation PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
K29 Sumoylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
T33 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
T40 Phosphorylation PhosphoSitePlus
T43 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K70 Acetylation PhosphoSitePlus   UniProt 19608861
K70 Sumoylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
T74 Phosphorylation PhosphoSitePlus
K76 Acetylation PhosphoSitePlus   UniProt 19608861
K76 Ubiquitination PhosphoSitePlus
K79 Acetylation PhosphoSitePlus   UniProt 19608861
K79 Ubiquitination PhosphoSitePlus
K86 Acetylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
S88 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...30379171, 34725712, 34019948, 33465208
S88 Phosphorylation PhosphoSitePlus
Y91 Phosphorylation PhosphoSitePlus
Y94 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107, 20068231
K97 Acetylation PhosphoSitePlus   UniProt 19608861
K97 Ubiquitination PhosphoSitePlus
K101 Acetylation PhosphoSitePlus   UniProt 16916647
K101 Ubiquitination PhosphoSitePlus
T105 Phosphorylation PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
K126 Sumoylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
Y129 Phosphorylation PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
T196 Phosphorylation HPRD 20068231
K242 Ubiquitination PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
T254 Phosphorylation PhosphoSitePlus
Y256 Phosphorylation PhosphoSitePlus
Y257 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
T264 O-Glycosylation GlyGen 35008409, 33214551, 35138101, ...30379171, 34725712, 34019948, 33465208
T264 Phosphorylation PhosphoSitePlus
T268 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
Y297 Phosphorylation PhosphoSitePlus
S298 Phosphorylation HPRD   PhosphoSitePlus 18491316
K301 Ubiquitination PhosphoSitePlus
K309 Acetylation PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R6 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
R18 W18 Biomuta DOID:263 / kidney cancer [ cosmic ]
K29 E29 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K76 T76 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K76 I76 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K101 N101 Biomuta DOID:363 / uterine cancer [ icgc ]
T105 K105 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T118 I118 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K126 R126 Biomuta DOID:363 / uterine cancer [ cosmic ]
T196 P196 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T196 I196 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S275 F275 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K290 N290 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]