iPTMnet Report for P08729 (KRT7)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08729 / K2C7_HUMAN
Protein Name Keratin, type II cytoskeletal 7
Gene Name Name: KRT7
Synonyms:SCL;
Organism Homo sapiens (Human)

PRO ID PR:P08729
DAG View
PRO Name keratin, type II cytoskeletal 7 (human)
Definition A keratin, type II cytoskeletal 7 that is encoded in the genome of human.
Short Label hKRT7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08729 (KRT7) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 17081983, 19007248
S6 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
S7 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 19007248
S12 O-Glycosylation GlyGen 33214551, 26853435, 23576270, ...34019948, 35083852, 35289036, 22121020
R13 Methylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
R20 Methylation PhosphoSitePlus
R25 Methylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
S28 Phosphorylation HPRD   PhosphoSitePlus 18669648
R30 Methylation PhosphoSitePlus
S36 Phosphorylation HPRD   PhosphoSitePlus 18669648, 19007248
S37 Phosphorylation HPRD   PhosphoSitePlus 17389395
S38 Phosphorylation HPRD   PhosphoSitePlus 19007248
Y40 Phosphorylation HPRD   PhosphoSitePlus 17389395
S45 Phosphorylation HPRD   PhosphoSitePlus 17924679
R46 Methylation PhosphoSitePlus
R48 Methylation PhosphoSitePlus
R52 Methylation PhosphoSitePlus
S53 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18212344, 19007248
Y55 Phosphorylation PhosphoSitePlus
R64 Methylation PhosphoSitePlus
T67 Phosphorylation HPRD   PhosphoSitePlus 18212344
S71 Phosphorylation IEDB   PhosphoSitePlus   UniProt 32387766, 23186163
R77 Methylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus   UniProt 23186163
K96 Ubiquitination PhosphoSitePlus
T97 Phosphorylation PhosphoSitePlus   UniProt 23186163
K101 Acetylation PhosphoSitePlus
K101 Methylation PhosphoSitePlus
K101 Sumoylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K117 Acetylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K122 Acetylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K130 Sumoylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
K179 Acetylation PhosphoSitePlus   UniProt 19608861
Y180 Phosphorylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K199 Acetylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
Y205 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
S207 Phosphorylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
T227 Phosphorylation HPRD   PhosphoSitePlus 18452278
T231 Phosphorylation HPRD   PhosphoSitePlus 18452278
T234 Phosphorylation HPRD   PhosphoSitePlus 18452278
S238 Phosphorylation HPRD   PhosphoSitePlus 18452278
S241 Phosphorylation PhosphoSitePlus
T243 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S252 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648
S254 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
K265 Ubiquitination PhosphoSitePlus
Y268 Phosphorylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
Y283 Phosphorylation PhosphoSitePlus
K286 Acetylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
T289 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18212344
K296 Acetylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K326 Sumoylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
R329 Methylation PhosphoSitePlus
K331 Acetylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
Y375 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
S380 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
K394 Acetylation PhosphoSitePlus
K394 Sumoylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
R458 Methylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
R464 Methylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 P2 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S12 L12 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R13 S13 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S18 L18 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R25 H25 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R30 C30 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S37 R37 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S45 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S45 L45 Biomuta DOID:363 / uterine cancer [ cosmic ]
R48 C48 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y55 C55 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R64 C64 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R64 H64 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T67 I67 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R77 Q77 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S83 C83 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S83 F83 Biomuta DOID:4159 / skin cancer [ cosmic ]
S104 C104 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K214 N214 Biomuta DOID:363 / uterine cancer [ icgc ]
T231 M231 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T234 A234 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S241 F241 Biomuta DOID:4159 / skin cancer [ cosmic ]
K265 N265 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T289 I289 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
R329 L329 Biomuta DOID:1324 / lung cancer [ cosmic ]
R329 C329 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S461 F461 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R464 C464 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R464 S464 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]