iPTMnet Report for P08651 (NFIC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08651 / NFIC_HUMAN
Protein Name Nuclear factor 1 C-type
Gene Name Name: NFIC
Synonyms:NFI;
Organism Homo sapiens (Human)

PRO ID PR:P08651
DAG View
PRO Name nuclear factor 1 C-type (human)
Definition A nuclear factor 1 C-type that is encoded in the genome of human.
Short Label hNFIC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08651 (NFIC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 20068231
S4 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K58 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
S192 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S194 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 20068231, 24275569, ...17081983
T237 Phosphorylation PhosphoSitePlus
T270 O-Glycosylation GlyGen 34846842
T270 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S275 O-Glycosylation GlyGen 33214551, 31492838, 35254053, ...34019948, 29485866, 35289036, 30059200
S275 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S277 O-Glycosylation GlyGen 33214551, 31492838, 35254053, ...34019948, 29485866, 35289036, 30059200
S277 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
K280 Acetylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
T293 Phosphorylation PhosphoSitePlus
S294 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y299 Phosphorylation PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
S304 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569, 18220336
S305 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
T307 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
T314 Phosphorylation PhosphoSitePlus
S322 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S323 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...20068231
T328 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S333 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 15302935, ...18669648, 24275569, 19690332, 20068231
S337 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S339 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...15302935, 18669648, 24275569, 20068231
S343 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18669648, ...24275569, 20068231
R345 Methylation PhosphoSitePlus
T350 Phosphorylation PhosphoSitePlus
R354 Methylation PhosphoSitePlus
S361 O-Glycosylation GlyGen 33214551, 31492838, 35254053, ...34019948, 29485866, 35289036, 30059200
S361 Phosphorylation PhosphoSitePlus
R365 Methylation PhosphoSitePlus   UniProt 24129315
S366 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
R395 Methylation PhosphoSitePlus   UniProt 24129315
S427 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
R451 Methylation PhosphoSitePlus   UniProt 24129315
T462 O-Glycosylation GlyGen 33214551, 31492838, 35254053, ...34019948, 29485866, 35289036, 30059200
T463 O-Glycosylation GlyGen 33214551, 31492838, 35254053, ...34019948, 29485866, 35289036, 30059200
S464 O-Glycosylation GlyGen 33214551, 31492838, 35254053, ...34019948, 29485866, 35289036, 30059200
T472 Phosphorylation PhosphoSitePlus
S473 O-Glycosylation GlyGen 34846842
S473 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y476 Phosphorylation PhosphoSitePlus
S477 O-Glycosylation GlyGen 34846842
S477 Phosphorylation PhosphoSitePlus   UniProt 24275569
T481 Phosphorylation PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus   UniProt 20068231
Site PTM Type PTM Enzyme Score Source PMID
S183 Phosphorylation HPRD 19651622, 17081983, 20068231
S185 Phosphorylation HPRD 19651622, 15302935, 20068231
T228 Phosphorylation HPRD 20068231
S277 Phosphorylation HPRD 18452278
S285 Phosphorylation HPRD 18669648, 18452278
S295 Phosphorylation HPRD 18669648, 20068231, 18452278
S296 Phosphorylation HPRD 18669648, 20068231, 18452278
S313 Phosphorylation HPRD 18691976, 18669648, 20068231, ...18452278
S314 Phosphorylation HPRD 18691976, 18767875, 18452278, ...19651622, 17322306, 18669648, 20068231
T319 Phosphorylation HPRD 18669648
S324 Phosphorylation HPRD 15302935, 20058876, 18452278, ...19651622, 18669648, 20068231
S328 Phosphorylation HPRD 19651622, 17081983, 20068231, ...18452278
S330 Phosphorylation HPRD 17322306, 18767875, 20058876, ...18452278, 19651622, 18669648, 20166139, 20068231
S334 Phosphorylation HPRD 19651622, 20068231, 18452278
S357 Phosphorylation HPRD 20068231
S478 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y2 Phosphorylation HPRD 20068231
S3 Phosphorylation HPRD 20068231
S4 Phosphorylation HPRD 17081983, 20068231
S192 Phosphorylation HPRD 19651622, 17081983, 20068231
S194 Phosphorylation HPRD 19651622, 15302935, 20068231
T237 Phosphorylation HPRD 20068231
S286 Phosphorylation HPRD 18452278
S294 Phosphorylation HPRD 18669648, 18452278
S304 Phosphorylation HPRD 18669648, 20068231, 18452278
S305 Phosphorylation HPRD 18669648, 20068231, 18452278
S322 Phosphorylation HPRD 18691976, 18669648, 20068231, ...18452278
S323 Phosphorylation HPRD 18691976, 18767875, 18452278, ...19651622, 17322306, 18669648, 20068231
T328 Phosphorylation HPRD 18669648
S333 Phosphorylation HPRD 15302935, 20058876, 18452278, ...19651622, 18669648, 20068231
S337 Phosphorylation HPRD 19651622, 17081983, 20068231, ...18452278
S339 Phosphorylation HPRD 17322306, 18767875, 20058876, ...18452278, 19651622, 18669648, 20166139, 20068231
S343 Phosphorylation HPRD 19651622, 20068231, 18452278
S366 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 F4 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T146 I146 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S276 C276 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S277 L277 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S277 N277 Biomuta DOID:4159 / skin cancer [ cosmic ]
S284 L284 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S286 L286 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T307 S307 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S310 N310 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S313 L313 Biomuta DOID:4159 / skin cancer [ cosmic ]
S322 L322 Biomuta DOID:4159 / skin cancer [ cosmic ]
S330 F330 Biomuta DOID:363 / uterine cancer [ cosmic ]
S330 P330 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S334 F334 Biomuta DOID:1612 / breast cancer [ cosmic ]
S339 P339 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S339 F339 Biomuta DOID:363 / uterine cancer [ cosmic ]
S343 F343 Biomuta DOID:1612 / breast cancer [ cosmic ]
R345 C345 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R354 W354 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S357 N357 Biomuta DOID:10283 / prostate cancer [ cosmic, cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
S361 I361 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R365 W365 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S366 N366 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R395 H395 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]