iPTMnet Report for P08621 (SNRNP70)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08621 / RU17_HUMAN
Protein Name U1 small nuclear ribonucleoprotein 70 kDa
Gene Name Name: SNRNP70
Synonyms:RNPU1Z,RPU1,SNRP70,U1AP1;
Organism Homo sapiens (Human)

PRO ID PR:P08621
DAG View
PRO Name U1 small nuclear ribonucleoprotein 70 kDa (human)
Definition A U1 small nuclear ribonucleoprotein 70 kDa that is encoded in the genome of human.
Short Label hSNRNP70
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08621 (SNRNP70) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 19413330, 22223895
K27 Ubiquitination PhosphoSitePlus
Y38 Phosphorylation PhosphoSitePlus
C39 S-Nitrosylation dbSNO 26338901
T58 O-Glycosylation GlyGen 33214551, 34725712, 30620550, ...34019948, 35083852, 32119511, 28510447
T84 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K103 Acetylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
Y112 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
K118 Acetylation PhosphoSitePlus   UniProt 19608861
K118 Ubiquitination PhosphoSitePlus
Y126 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 23186163
K130 Methylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus   RLIMS-P 19035498, 18202700
Y146 Phosphorylation PhosphoSitePlus
Y151 Phosphorylation PhosphoSitePlus
Y161 Phosphorylation PhosphoSitePlus
K162 Acetylation PhosphoSitePlus
R180 Methylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
T199 Phosphorylation PhosphoSitePlus
R201 Methylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus
S226 Phosphorylation P24941 (CDK2) phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...17081983, 18847512, 15144186, 18669648, 24275569, 20068231, 17924679
S257 Phosphorylation PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus
S266 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S268 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S277 Phosphorylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
R310 Methylation PhosphoSitePlus
S320 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 19690332, 20068231
K346 Methylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
R393 Methylation PhosphoSitePlus
S410 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...16964243, 18669648, 19690332, 20068231, 17081983
Y414 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y126 Phosphorylation HPRD 18083107
S137 Phosphorylation HPRD 12548559
S140 Phosphorylation HPRD 12548559
S226 Phosphorylation HPRD 18691976, 18212344, 18767875, ...19664995, 18452278, 19651622, 17322306, 18669648, 20166139, 17924679, 19415658, 20068231, 20068230
S266 Phosphorylation HPRD 17081983
S268 Phosphorylation HPRD 17081983, 20068231
S320 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 19664995
S357 Phosphorylation HPRD 20068231
S360 Phosphorylation HPRD 20068231
S410 Phosphorylation HPRD 19413330, 18691976, 17081983, ...19664994, 19691289, 19664995, 19651622, 18669648, 18452278, 20068231, 18212344


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K27 T27 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T84 A84 Biomuta DOID:3571 / liver cancer [ cosmic ]
K87 T87 Biomuta DOID:4159 / skin cancer [ cosmic ]
K103 N103 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S137 G137 Biomuta DOID:363 / uterine cancer [ icgc ]
S211 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S211 L211 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S295 C295 Biomuta DOID:10534 / stomach cancer [ icgc ]
R310 H310 Biomuta DOID:4159 / skin cancer [ cosmic ]
R393 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S410 N410 Biomuta DOID:1324 / lung cancer [ cosmic ]