iPTMnet Report for P08559 (PDHA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08559 / ODPA_HUMAN
Protein Name Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor
Gene Name Name: PDHA1
Synonyms:PHE1A;
Organism Homo sapiens (Human)

PRO ID PR:P08559
DAG View
PRO Name pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (human)
Definition A pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial that is encoded in the genome of human.
Short Label hPDHA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08559 (PDHA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S13 O-Glycosylation GlyGen 36580660, 34725712, 29351928, ...35083852, 32119511, 22121020, 34229054
K18 Acetylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
K39 Acetylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K63 Acetylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K77 Acetylation PhosphoSitePlus
K83 Acetylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
T116 Phosphorylation PhosphoSitePlus
Y118 Phosphorylation PhosphoSitePlus
T139 Phosphorylation PhosphoSitePlus
K149 Acetylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
Y227 Phosphorylation PhosphoSitePlus
T231 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S232 Phosphorylation Q15118 (PDK1) , O15530 (PDPK1) , Q15119 (PDK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...7273851, 18220336, 15302935, 29191787, 11486000, 7782287, 22195962, 18088087, 11092882, 11485553, 31354221, 20068231, 16436377
S239 Phosphorylation PhosphoSitePlus
T240 Phosphorylation PhosphoSitePlus
Y242 Phosphorylation PhosphoSitePlus
Y243 Phosphorylation PhosphoSitePlus
K244 Acetylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
R245 Methylation PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
K277 Acetylation PhosphoSitePlus
Y289 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18083107, 26848621, 16497976
S293 Phosphorylation Q16654 (PDK4) , Q15119 (PDK2) , O15530 (PDPK1) , Q15120 (PDK3) , Q15118 (PDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22910903, 17081983, 7273851, ...18220336, 31100640, 29191787, 15302935, 7782287, 17474719, 19081061, 22195962, 33022274, 11092882, 11485553, 31354221, 11486000, 16436377
S295 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 33336150, 18220336, 33022274, ...17081983
S300 Phosphorylation Q15119 (PDK2) , Q15118 (PDK1) , Q16654 (PDK4) , Q15120 (PDK3) , O15530 (PDPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22910903, 16436377, 7273851, ...18220336, 15302935, 11486000, 7782287, 17474719, 19081061, 22195962, 11092882, 11485553, 31354221, 17081983
Y301 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18220336, 18083107, 26848621, ...25104357, 16497976
T303 Phosphorylation PhosphoSitePlus
K313 Acetylation PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus   RLIMS-P 33336150, 33022274
K321 Acetylation PhosphoSitePlus   UniProt 19608861
K321 Ubiquitination PhosphoSitePlus
K336 Acetylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
Y366 Phosphorylation PhosphoSitePlus
Y369 Phosphorylation PhosphoSitePlus
K385 Acetylation PhosphoSitePlus
K385 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y227 Phosphorylation HPRD 20068231
T231 Phosphorylation HPRD 19413330, 18691976, 18767875, ...18669648, 20166139, 19415658, 20068231
S232 Phosphorylation PR:Q15118 (hPDK1) , Q15118 (PDK1) , Q15120 (PDK3) HPRD   PRO 18691976, 18088087, 18212344, ...20058876, 15302935, 19341700, 7782287, 18767875, 20166139, 11485553, 19415658, 20068231
Y289 Phosphorylation HPRD 20166139, 16497976
S293 Phosphorylation PR:Q15119 (hPDK2) , Q15119 (PDK2) , PR:Q15118 (hPDK1) , Q15118 (PDK1) , Q16654 (PDK4) , PR:Q15120 (hPDK3) , PR:Q16654 (hPDK4) , Q15120 (PDK3) HPRD   PRO 18691976, 18212344, 18767875, ...11486000, 19341700, 7782287, 20166139, 11485553, 19415658, 12676647
S295 Phosphorylation HPRD 20166139, 18767875
S300 Phosphorylation Q16654 (PDK4) , PR:Q15118 (hPDK1) , Q15119 (PDK2) , PR:Q16654 (hPDK4) , PR:Q15119 (hPDK2) , Q15118 (PDK1) , PR:Q15120 (hPDK3) HPRD   PRO 18691976, 18212344, 11486000, ...19341700, 7782287, 20166139, 11485553, 19415658, 12676647
Y301 Phosphorylation HPRD 18083107, 18691976, 16497976, ...20166139, 19415658
Y369 Phosphorylation HPRD 18083107
Site PTM Type PTM Enzyme Score Source PMID
S300 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044826 (hPDHA1/TransPep-/Phos:1) pS232 PR:Q15118 (hPDK1) PRO 11485553, 19341700, 7782287
PR:000044827 (hPDHA1/TransPep-/Phos:2) pS293 PR:Q15118 (hPDK1) PRO 11485553, 19341700, 7782287
PR:000044827 (hPDHA1/TransPep-/Phos:2) pS293 PR:Q15119 (hPDK2) PRO 11485553, 19341700, 7782287
PR:000044827 (hPDHA1/TransPep-/Phos:2) pS293 PR:Q15120 (hPDK3) PRO 11485553, 19341700, 7782287
PR:000044827 (hPDHA1/TransPep-/Phos:2) pS293 PR:Q16654 (hPDK4) PRO 11485553, 19341700, 7782287
PR:000044828 (hPDHA1/TransPep-/Phos:3) pS300 PR:Q15118 (hPDK1) PRO 11485553, 19341700, 7782287
PR:000044828 (hPDHA1/TransPep-/Phos:3) pS300 PR:Q16654 (hPDK4) PRO 11485553, 19341700, 7782287
PR:000044828 (hPDHA1/TransPep-/Phos:3) pS300 PR:Q15120 (hPDK3) PRO 11485553, 19341700, 7782287
PR:000044828 (hPDHA1/TransPep-/Phos:3) pS300 PR:Q15119 (hPDK2) PRO 11485553, 19341700, 7782287
PR:000044832 (hPDHA1/TransPep-/Phos:4) pS293,pS300 PRO
PR:000044833 (hPDHA1/TransPep-/Phos:5) pS293 PRO
PR:000044834 (hPDHA1/TransPep-/Phos:6) pS300 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S13 C13 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S152 L152 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T231 M231 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
S232 F232 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y243 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y243 H243 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K277 N277 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K321 E321 Biomuta DOID:4159 / skin cancer [ cosmic ]