iPTMnet Report for P08069 (IGF1R)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08069 / IGF1R_HUMAN
Protein Name Insulin-like growth factor 1 receptor precursor
Gene Name Name: IGF1R
Organism Homo sapiens (Human)

PRO ID PR:P08069
DAG View
PRO Name insulin-like growth factor 1 receptor (human)
Definition An insulin-like growth factor 1 receptor that is encoded in the genome of human.
Short Label hIGF1R
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08069 (IGF1R) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation RLIMS-P 26041671
N51 N-Glycosylation GlyGen   UniProt 9690478
Y113 Phosphorylation PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
N135 N-Glycosylation GlyGen   UniProt 9690478
N244 N-Glycosylation GlyGen   UniProt 9690478
N314 N-Glycosylation GlyGen   UniProt 9690478
T468 Phosphorylation HPRD 20068231
R471 Methylation PhosphoSitePlus
S473 Phosphorylation RLIMS-P 24205274
R480 Methylation PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
N638 N-Glycosylation GlyGen 24190977
N640 N-Glycosylation GlyGen 24190977
K672 Ubiquitination PhosphoSitePlus
T684 O-Glycosylation GlyGen 30459171
N747 N-Glycosylation GlyGen 23090970, 24190977
N900 N-Glycosylation GlyGen 23090970, 24190977
Y973 Phosphorylation P12931 (SRC) , P08069 (IGF1R) HPRD   IntAct   phospho.ELM   PhosphoSitePlus 9480911, 8550552, 10026153, ...17016520, 8940173
Y980 Phosphorylation P08069 (IGF1R) , P12931 (SRC) HPRD   IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 9480911, 8550552, 7642582, ...7537849, 11591350, 30653502, 7541045, 8940173, 7559478
S982 Phosphorylation P08069 (IGF1R) PhosphoSitePlus 11591350
S1009 Phosphorylation PhosphoSitePlus
Y1014 Phosphorylation PhosphoSitePlus
K1033 Ubiquitination PhosphoSitePlus
K1055 Sumoylation PhosphoSitePlus
K1088 Acetylation PhosphoSitePlus
K1130 Sumoylation PhosphoSitePlus
K1150 Sumoylation PhosphoSitePlus
Y1161 Phosphorylation P12931 (SRC) , P08069 (IGF1R) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17016520, 18501599, 8550552, ...11591350, 18691976, 7798258, 11694888, 16793764, 33328764, 18083107, 24648957, 8940173, 7493944, 15334055, 19041240
T1163 Phosphorylation PhosphoSitePlus
Y1165 Phosphorylation P12931 (SRC) , P08069 (IGF1R) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 17016520, 17389395, 18501599, ...11694888, 11591350, 18691976, 7798258, 8550552, 16793764, 18566589, 18083107, 8940173, 15334055, 7493944, 20068231, 19041240
Y1166 Phosphorylation P08069 (IGF1R) , P12931 (SRC) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18501599, 11694888, 11591350, ...7798258, 8550552, 16793764, 18083107, 8940173, 7493944, 15334055, 19041240
K1168 Ubiquitination PhosphoSitePlus   UniProt 21994939
K1171 Ubiquitination PhosphoSitePlus   UniProt 21994939
S1193 Phosphorylation PhosphoSitePlus
S1278 Phosphorylation P25098 (GRK2) HPRD   PhosphoSitePlus 18691976, 22509025
Y1280 Phosphorylation P08069 (IGF1R) HPRD   phospho.ELM   PhosphoSitePlus 8972223, 8940173
Y1281 Phosphorylation P08069 (IGF1R) HPRD   phospho.ELM   PhosphoSitePlus 8972223, 8550552
S1308 Phosphorylation HPRD 18691976
S1310 Phosphorylation HPRD   PhosphoSitePlus 18691976
S1311 Phosphorylation PhosphoSitePlus
S1312 Phosphorylation PhosphoSitePlus
S1313 Phosphorylation PhosphoSitePlus
S1321 Phosphorylation P43250 (GRK6) PhosphoSitePlus 22509025
S1339 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648
Y1346 Phosphorylation P08069 (IGF1R) HPRD   IntAct   phospho.ELM   PhosphoSitePlus 8550552, 7642582, 8895367, ...10026153, 7589433, 9415396, 8603569
K1354 Methylation PhosphoSitePlus
S1364 Phosphorylation HPRD 18691976, 18767875
T1366 Phosphorylation HPRD   PhosphoSitePlus 18691976, 20068231, 18767875
C1367 S-Nitrosylation dbSNO 26338901


P08069 (IGF1R) as PTM Enzyme



Substrate Site Score Source PMID
O15530 (PDPK1) Y373 PhosphoSitePlus   Signor 20044479, 20643654
O15530 (PDPK1) Y376 PhosphoSitePlus   Signor 20044479, 20643654
P07550 (ADRB2) Y132 phospho.ELM 8910597
P07550 (ADRB2) Y141 phospho.ELM 8910597
P08069 (IGF1R) Y973 phospho.ELM 8940173, 8550552
P08069 (IGF1R) Y980 phospho.ELM   PhosphoSitePlus 8940173, 8550552, 11591350
P08069 (IGF1R) S982 PhosphoSitePlus 11591350
P08069 (IGF1R) Y1161 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 11694888, 11591350, 7798258, ...8550552, 8940173, 7493944, 15334055, 16793764
P08069 (IGF1R) Y1165 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 16793764, 11591350, 7798258, ...8550552, 18566589, 8940173, 7493944, 15334055, 11694888
P08069 (IGF1R) Y1166 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 16793764, 11591350, 7798258, ...8550552, 8940173, 7493944, 15334055, 11694888
P08069 (IGF1R) Y1280 phospho.ELM   PhosphoSitePlus 8972223, 8940173
P08069 (IGF1R) Y1281 phospho.ELM   PhosphoSitePlus 8972223, 8550552
P08069 (IGF1R) Y1346 phospho.ELM 8550552
P35568 (IRS1) Y465 Signor 17827393
P35568 (IRS1) Y612 Signor 17827393
P35568 (IRS1) Y632 PhosphoSitePlus   Signor 17827393, 8530377
P35568 (IRS1) Y662 PhosphoSitePlus 8530377
P35568 (IRS1) Y732 PhosphoSitePlus 8530377
P35568 (IRS1) Y896 HPRD   PhosphoSitePlus   Signor 17827393, 8530377
P35568 (IRS1) Y941 PhosphoSitePlus   Signor 17827393, 8530377
P35568 (IRS1) Y989 PhosphoSitePlus   Signor 17827393, 8530377
P35568 (IRS1) Y1179 PhosphoSitePlus   Signor 17827393, 8530377
P35568 (IRS1) Y1229 Signor 17827393
P46108 (CRK) Y221 HPRD   neXtProt 11956190, 9480911, 9642287, ...8875975, 12198159, 17016520, 20068231
P78324 (SIRPA) Y470 PhosphoSitePlus 21799000
P78324 (SIRPA) Y496 PhosphoSitePlus 21799000


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35568 (IRS1) Y612 P08069 (IGF1R) increased_association eFIP 17902048