iPTMnet Report for P07996 (THBS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07996 / TSP1_HUMAN
Protein Name Thrombospondin-1 precursor
Gene Name Name: THBS1
Synonyms:TSP,TSP1;
Organism Homo sapiens (Human)

PRO ID PR:P07996
DAG View
PRO Name thrombospondin-1 (human)
Definition A thrombospondin-1 that is encoded in the genome of human.
Short Label hTHBS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07996 (THBS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S56 Phosphorylation PhosphoSitePlus
T150 O-Glycosylation GlyGen 33214551, 34725712, 34019948, ...22403705, 29351928
K173 Ubiquitination PhosphoSitePlus
N248 N-Glycosylation GlyGen   UniProt 16335952, 32125861, 24190977, ...23090970, 18065761, 16263699, 29741879
K262 Ubiquitination PhosphoSitePlus
C270 Methylation IEDB 31844290
T289 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T292 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T293 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T302 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
K306 Ubiquitination PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
N360 N-Glycosylation GlyGen 29741879, 32125861
W385 C-Glycosylation GlyGen 11067851
S394 O-Glycosylation GlyGen 11067851
W438 C-Glycosylation GlyGen 11067851
W441 C-Glycosylation GlyGen 11067851
T450 O-Glycosylation GlyGen 11067851, 12391027
K472 Ubiquitination PhosphoSitePlus
T481 Phosphorylation PhosphoSitePlus
W498 C-Glycosylation GlyGen 11067851
T507 O-Glycosylation GlyGen 11067851, 12391027
N521 N-Glycosylation GlyGen 29391424
T563 Phosphorylation PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
Y565 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
S580 O-Glycosylation GlyGen 33214551, 34725712, 34019948, ...22403705, 29351928
S627 Phosphorylation PhosphoSitePlus
T638 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
N708 N-Glycosylation GlyGen 23090970, 29741879, 24190977
Y817 Phosphorylation PhosphoSitePlus
Y1022 Phosphorylation PhosphoSitePlus
Y1029 Phosphorylation PhosphoSitePlus
S1033 Phosphorylation PhosphoSitePlus
Y1036 Phosphorylation PhosphoSitePlus
N1051 N-Glycosylation GlyGen 29391424
Y1058 Phosphorylation PhosphoSitePlus
N1067 N-Glycosylation GlyGen   UniProt 16335952, 32125861, 19159218, ...15014436, 29391424, 16740002, 23345538, 29741879, 29671580
Site PTM Type PTM Enzyme Score Source PMID
N360 N-Glycosylation PRO 29741879
W385 C-Glycosylation PRO 12450399, 11067851, 15342643, ...3305519
S394 O-Glycosylation PRO 12450399, 11067851, 15342643, ...3305519
W438 C-Glycosylation PRO 12450399, 11067851, 15342643, ...3305519
W441 C-Glycosylation PRO 12450399, 11067851, 15342643, ...3305519
T450 O-Glycosylation PRO 12450399, 11067851, 15342643, ...3305519
W498 C-Glycosylation PRO 12450399, 11067851, 15342643, ...3305519
T507 O-Glycosylation PRO 12450399, 11067851, 15342643, ...3305519
N1067 N-Glycosylation PRO 29741879, 29671580, 23345538


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036488 (hTHBS1/iso:1/SigPep-/Glyco:1) Interaction PR:000028966 (hTHBS1/iso:1/Clv:2) PRO 3305519


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T293 M293 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T302 I302 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y319 C319 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N360 D360 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
W438 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K472 N472 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S569 R569 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T638 M638 Biomuta DOID:3571 / liver cancer [ cosmic ]