iPTMnet Report for P07992 (ERCC1)
Protein Information
UniProt AC / UniProt ID | P07992 / ERCC1_HUMAN |
Protein Name | DNA excision repair protein ERCC-1 |
Gene Name | Name: ERCC1 |
Organism | Homo sapiens (Human) |
PRO ID | PR:P07992 |
PRO Name | DNA excision repair protein ERCC-1 (human) |
Definition | A DNA excision repair protein ERCC-1 that is encoded in the genome of human. |
Short Label | hERCC1 |
Category | organism-gene |
P07992 (ERCC1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Ubiquitination | score1 | PRO | ||||
M1 | Acetylation | score1 | UniProt | 22814378 | ||
S14 | Phosphorylation | score1 | PhosphoSitePlus | |||
K21 | Ubiquitination | score1 | PhosphoSitePlus | |||
K37 | Acetylation | score1 | PhosphoSitePlus | |||
K37 | Ubiquitination | score1 | PhosphoSitePlus | |||
S104 | Phosphorylation | score1 | PhosphoSitePlus | |||
K114 | Ubiquitination | score1 | PhosphoSitePlus | |||
K162 | Ubiquitination | score1 | PhosphoSitePlus | |||
C194 | Methylation | score1 | IEDB | 31844290 | ||
K213 | Ubiquitination | score1 | PhosphoSitePlus | |||
K226 | Ubiquitination | score1 | PhosphoSitePlus | |||
C238 | Methylation | score1 | IEDB | 31844290 | ||
K243 | Ubiquitination | score1 | PhosphoSitePlus | |||
K247 | Ubiquitination | score1 | PhosphoSitePlus | |||
K281 | Ubiquitination | score1 | PhosphoSitePlus | |||
K295 | Acetylation | score1 | PhosphoSitePlus | |||
K295 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K281 | Ubiquitination | score1 | PhosphoSitePlus | |||
S307 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S14 | L14 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
S14 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K21 | T21 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |