iPTMnet Report for P07951 (TPM2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07951 / TPM2_HUMAN
Protein Name Tropomyosin beta chain
Gene Name Name: TPM2
Synonyms:TMSB;
Organism Homo sapiens (Human)

PRO ID PR:P07951
DAG View
PRO Name tropomyosin beta chain (human)
Definition A tropomyosin beta chain that is encoded in the genome of human.
Short Label hTPM2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07951 (TPM2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K12 Acetylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
K29 Acetylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
K48 Acetylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
T53 Phosphorylation PhosphoSitePlus   UniProt 24692096
K59 Ubiquitination PhosphoSitePlus
Y60 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K76 Acetylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
T79 Phosphorylation PhosphoSitePlus   UniProt 24692096
S87 Phosphorylation PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus   UniProt 24692096
K112 Acetylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K118 Acetylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
K128 Sumoylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K140 Acetylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus   UniProt 24692096
K161 Acetylation PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
K168 Acetylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus   UniProt 24692096
K213 Acetylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K220 Acetylation PhosphoSitePlus
K220 Methylation PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
Y221 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
K248 Acetylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus   UniProt 24692096
Y261 Phosphorylation PhosphoSitePlus
Y267 Phosphorylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus   UniProt 24692096
S283 Phosphorylation PhosphoSitePlus   UniProt 24692096
Site PTM Type PTM Enzyme Score Source PMID
S87 Phosphorylation HPRD 19664994
Site PTM Type PTM Enzyme Score Source PMID
S61 Phosphorylation P48736 (PIK3CG) HPRD 16094730
S87 Phosphorylation HPRD 19664994
S206 Phosphorylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
T252 Phosphorylation HPRD   PhosphoSitePlus 19651622
S262 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S61 Y61 Biomuta DOID:363 / uterine cancer [ cosmic ]
S63 F63 Biomuta DOID:4159 / skin cancer [ cosmic ]
K65 E65 Biomuta DOID:1319 / brain cancer [ cosmic ]
K118 T118 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S123 R123 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S206 F206 Biomuta DOID:4159 / skin cancer [ cosmic ]
T237 N237 Biomuta DOID:3571 / liver cancer [ cosmic ]
S245 F245 Biomuta DOID:4159 / skin cancer [ cosmic ]
S262 G262 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
T282 P282 Biomuta DOID:2394 / ovarian cancer [ cosmic ]