iPTMnet Report for P07949 (RET)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07949 / RET_HUMAN
Protein Name Proto-oncogene tyrosine-protein kinase receptor Ret precursor
Gene Name Name: RET
Synonyms:CDHF12,CDHR16,PTC,RET51;
Organism Homo sapiens (Human)

PRO ID PR:P07949
DAG View
PRO Name proto-oncogene tyrosine-protein kinase receptor Ret (human)
Definition A proto-oncogene tyrosine-protein kinase receptor Ret that is encoded in the genome of human.
Short Label hRET
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07949 (RET) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N151 N-Glycosylation GlyGen   UniProt 20473317
S159 Phosphorylation PhosphoSitePlus
T350 Phosphorylation PhosphoSitePlus
T675 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   RLIMS-P 22128160
S686 Phosphorylation PhosphoSitePlus
Y687 Phosphorylation P07949 (RET) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 11470823, 24560924, 8621380, ...20682772, 24349301
S688 Phosphorylation PhosphoSitePlus
S696 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19369195, 20682772, 11886862
S699 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
Y752 Phosphorylation IntAct   PhosphoSitePlus 11536047
T754 Phosphorylation PhosphoSitePlus
Y791 Phosphorylation phospho.ELM   PhosphoSitePlus 15753368
Y806 Phosphorylation P07949 (RET) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14711813, 19029224
Y809 Phosphorylation P07949 (RET) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14711813
Y826 Phosphorylation P07949 (RET) neXtProt   phospho.ELM   PhosphoSitePlus 11470823, 8621380
Y864 Phosphorylation PhosphoSitePlus
S891 Phosphorylation phospho.ELM   PhosphoSitePlus 15753368
Y900 Phosphorylation P07949 (RET) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14711813, 24560924, 16928683
S904 Phosphorylation PhosphoSitePlus
Y905 Phosphorylation Q05397 (PTK2) , P07949 (RET) , P12931 (SRC) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 35689816, 19900702, 25047660, ...20117004, 32345963, 29434222, 28846099, 21454698, 27226544, 11713247, 17471236, 17599050, 18248647, 14711813, 16928683, 29665843, 24560924, 11956105, 32298114, 28460442, 12091387
S909 Phosphorylation PhosphoSitePlus
Y928 Phosphorylation IntAct   PhosphoSitePlus 11536047
Y952 Phosphorylation PhosphoSitePlus
Y981 Phosphorylation P07949 (RET) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14711813, 17471236, 14766744, ...24560924, 32062451, 16569669
Y1015 Phosphorylation P07949 (RET) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11713247, 11470823, 8621380, ...8662982, 9047383, 14981541, 24560924, 12091387, 11061555, 8628282
Y1029 Phosphorylation P07949 (RET) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 11470823, 24560924, 14766744, ...8621380
K1060 Ubiquitination PhosphoSitePlus
Y1062 Phosphorylation P07949 (RET) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 14981541, 11061555, 11313948, ...23056499, 28846099, 25675305, 27226544, 11713247, 31534554, 32062451, 15677445, 8663426, 22751117, 8621380, 11520496, 17599050, 16782438, 23429478, 11470823, 14711813, 29665843, 33672854, 24560924, 25409876, 16847065, 30701022, 29262623, 12755958, 12091387, 20629553, 11245446, 25720956
S1065 Phosphorylation PhosphoSitePlus
Y1090 Phosphorylation P07949 (RET) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14711813
Y1096 Phosphorylation P07949 (RET) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11713247, 11470823, 14711813, ...15677445, 8621380, 17599050
K1107 Ubiquitination PhosphoSitePlus
T1111 Phosphorylation PhosphoSitePlus
S1114 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y687 Phosphorylation P07949 (RET) HPRD 8621380
T753 Phosphorylation HPRD 20068231
T754 Phosphorylation HPRD 19413330, 20068231
Y806 Phosphorylation P07949 (RET) HPRD 14711813
Y809 Phosphorylation P07949 (RET) HPRD 14711813
Y826 Phosphorylation P07949 (RET) HPRD 8621380
Y900 Phosphorylation P07949 (RET) HPRD 14711813
Y905 Phosphorylation P07949 (RET) HPRD 10445857, 14711813, 8621380
Y981 Phosphorylation P07949 (RET) HPRD 14711813
Y1015 Phosphorylation P07949 (RET) HPRD 8621380
Y1029 Phosphorylation P07949 (RET) HPRD 8621380
Y1062 Phosphorylation P07949 (RET) HPRD 15677445, 14711813, 8621380
Y1090 Phosphorylation P07949 (RET) HPRD 14711813
Y1096 Phosphorylation P07949 (RET) HPRD 15677445, 14711813, 8621380
Site PTM Type PTM Enzyme Score Source PMID
Y687 Phosphorylation P07949 (RET) HPRD 8621380
G691 Phosphorylation PhosphoSitePlus
T753 Phosphorylation HPRD 20068231
T754 Phosphorylation HPRD 19413330, 20068231
Y806 Phosphorylation P07949 (RET) HPRD 14711813
Y809 Phosphorylation P07949 (RET) HPRD 14711813
Y826 Phosphorylation P07949 (RET) HPRD 8621380
Y900 Phosphorylation P07949 (RET) HPRD 14711813
Y905 Phosphorylation P07949 (RET) HPRD 10445857, 14711813
Y981 Phosphorylation P07949 (RET) HPRD 14711813
Y1015 Phosphorylation P07949 (RET) HPRD 8621380
Y1029 Phosphorylation P07949 (RET) HPRD 8621380
Y1062 Phosphorylation P07949 (RET) HPRD   PhosphoSitePlus 15588985, 11121408, 14711813, ...15677445, 8621380


P07949 (RET) as PTM Enzyme



Substrate Site Score Source PMID
O15530 (PDPK1) Y9 neXtProt   phospho.ELM   PhosphoSitePlus 12738763
P07949 (RET) Y687 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 11470823, 8621380
P07949 (RET) Y806 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 14711813
P07949 (RET) Y809 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 14711813
P07949 (RET) Y826 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 8621380
P07949 (RET) Y900 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 14711813, 16928683
P07949 (RET) Y905 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 10445857, 27226544, 14711813, ...11713247, 8621380
P07949 (RET) Y981 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 14711813, 14766744
P07949 (RET) Y1015 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 14981541, 11061555, 11713247, ...8621380
P07949-1 (RET) Y1029 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 14766744, 8621380
P07949 (RET) Y1062 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 15588985, 27226544, 11713247, ...11121408, 14981541, 14711813, 15677445, 8663426, 11061555, 8621380, 11245446
P07949-1 (RET) Y1090 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 14711813
P07949 (RET) Y1096 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15677445, 14711813, 11713247, ...8621380
P18848 (ATF4) T107 PhosphoSitePlus 25795775
P18848 (ATF4) T114 PhosphoSitePlus 25795775
P18848 (ATF4) T115 PhosphoSitePlus 25795775
P18848 (ATF4) T119 PhosphoSitePlus 25795775
P19174-1 (PLCG1) Y783 HPRD   neXtProt   PhosphoSitePlus 17016520, 17389395, 7682059, ...8657103, 20068231, 16153436, 1689310, 8885868, 16497976
P27361 (MAPK3) Y204 neXtProt   PhosphoSitePlus   Signor 16153436
P27986 (PIK3R1) Y203 neXtProt   PhosphoSitePlus 16153436
P28482 (MAPK1) Y187 HPRD   neXtProt   PhosphoSitePlus   Signor 17016520, 18691976, 18578522, ...17389395, 18452278, 19651622, 18669648, 16153436, 18707149, 19901323, 19415658, 20068231, 16497976
P31749 (AKT1) Y315 neXtProt   PhosphoSitePlus   Signor 15994200
P35222 (CTNNB1) Y654 neXtProt 18316596
P45983-1 (MAPK8) Y185 HPRD   neXtProt   PhosphoSitePlus 18669648, 16153436
P45984-4 (MAPK9) Y185 HPRD   neXtProt   PhosphoSitePlus 16153436
Q05397 (PTK2) Y576 HPRD   neXtProt   PhosphoSitePlus   Signor 17016520, 9507031, 17389395, ...19664994, 16153436, 7529876, 20068231, 21454698
Q05397 (PTK2) Y577 HPRD   neXtProt   PhosphoSitePlus   Signor 9507031, 7529876, 16153436, ...20068231, 21454698
Q05397 (PTK2) Y861 neXtProt   PhosphoSitePlus 16153436
Q05397 (PTK2) Y925 neXtProt   PhosphoSitePlus   Signor 16153436, 21454698
Q16539 (MAPK14) T180 Signor 17548358, 8622669, 7535770, ...17126298
Q16539-2 (MAPK14) Y182 HPRD   neXtProt   PhosphoSitePlus   Signor 17016520, 18691976, 18088087, ...17126298, 7535770, 18452278, 19651622, 18669648, 17548358, 8622669, 16153436, 19901323, 20068231, 16497976
Q658W2 (DKFZp666O0110) Y598 HPRD 17016520, 9507031, 17389395, ...19664994, 7529876, 20068231
Q658W2 (DKFZp666O0110) Y599 HPRD 9507031, 7529876, 20068231
Q8N4X5 (AFAP1L2) Y54 neXtProt   PhosphoSitePlus   Signor 19060924
Q99704-1 (DOK1) Y398 HPRD   neXtProt   PhosphoSitePlus 19901323, 11551902, 16153436, ...16497976


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049042 (hRET/SigPep-/Phos:2) pY905,pY981,pY1015,pY1062,pY1096 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P07949 (RET) Y1096 P62993 (GRB2) unknown eFIP 8621380


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T350 N350 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S686 R686 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S688 P688 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
G691 V691 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
G691 S691 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3565 / meningioma [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
S696 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S705 F705 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y752 H752 Biomuta DOID:4159 / skin cancer [ cosmic ]
T754 M754 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
Y791 N791 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y791 F791 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:3953 / adrenal gland cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
Y809 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y826 F826 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
Y826 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S891 A891 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S891 L891 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S891 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S904 L904 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S904 F904 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S904 Y904 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3119 / gastrointestinal system cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S904 P904 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K1060 R1060 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1090 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1114 N1114 Biomuta DOID:1319 / brain cancer [ cosmic ]