iPTMnet Report for P07741 (APRT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07741 / APT_HUMAN
Protein Name Adenine phosphoribosyltransferase
Gene Name Name: APRT
Organism Homo sapiens (Human)

PRO ID PR:P07741
DAG View
PRO Name adenine phosphoribosyltransferase (human)
Definition An adenine phosphoribosyltransferase that is encoded in the genome of human.
Short Label hAPRT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07741 (APRT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 19369195, 12665801, ...22814378, 22223895, 25944712
S4 Phosphorylation PhosphoSitePlus   UniProt 19369195
S15 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
T21 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus   UniProt 23186163
K34 Ubiquitination PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
R57 Methylation PhosphoSitePlus
Y60 Phosphorylation PhosphoSitePlus   UniProt 19369195
S66 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163, 24275569
T96 Phosphorylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
K114 Acetylation PhosphoSitePlus   UniProt 19608861
K114 Ubiquitination PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus   UniProt 19369195
K167 Acetylation PhosphoSitePlus
K167 Sumoylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R57 H57 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y60 H60 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]