iPTMnet Report for P07737 (PFN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07737 / PROF1_HUMAN
Protein Name Profilin-1
Gene Name Name: PFN1
Organism Homo sapiens (Human)

PRO ID PR:P07737
DAG View
PRO Name profilin-1 (human)
Definition A profilin-1 that is encoded in the genome of human.
Short Label hPFN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07737 (PFN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895, 3342873, ...25944712
Y7 Phosphorylation HPRD   PhosphoSitePlus 18491316
T16 Phosphorylation PhosphoSitePlus
Y25 Phosphorylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
K38 Acetylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
T44 Phosphorylation PhosphoSitePlus
K54 Acetylation PhosphoSitePlus
K54 Methylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
R56 Methylation PhosphoSitePlus
S57 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 20068231
Y60 Phosphorylation PhosphoSitePlus
T65 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus   UniProt 19690332
T90 Phosphorylation PhosphoSitePlus
K91 Acetylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
S92 Phosphorylation HPRD   PhosphoSitePlus 20068231
T93 Phosphorylation PhosphoSitePlus
T98 Phosphorylation PhosphoSitePlus
N100 N-Glycosylation GlyGen 24190977
T102 Phosphorylation PhosphoSitePlus
T104 Phosphorylation PhosphoSitePlus
K105 Acetylation PhosphoSitePlus   UniProt 19608861
K105 Ubiquitination PhosphoSitePlus
T106 Phosphorylation PhosphoSitePlus
K108 Acetylation PhosphoSitePlus   UniProt 19608861
K108 Ubiquitination PhosphoSitePlus
T109 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 26572741, 20068231
K116 Ubiquitination PhosphoSitePlus
K126 Acetylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
C128 Methylation IEDB 31844290
C128 S-Nitrosylation dbSNO 25040305, 2212679, 22126794, ...26338901
Y129 Phosphorylation P12931 (SRC) , P35968 (KDR) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17016520, 18083107, 15592455, ...23000962, 24747440
S133 Phosphorylation PhosphoSitePlus
S138 Phosphorylation Q13464 (ROCK1) neXtProt   PhosphoSitePlus   Signor   UniProt 22479341, 18573880
Y140 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P07737 (PFN1) Y129 P40337 (VHL) unknown eFIP 24747440
Phosphorylation P07737 (PFN1) T109 P60010 (ACT1) unknown eFIP 26572741


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S28 L28 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R56 Q56 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S77 L77 Biomuta [ cosmic ] DOID:1612 / breast cancer [ icgc ]
K91 N91 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T102 A102 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K105 E105 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K127 R127 Biomuta DOID:363 / uterine cancer [ icgc ]