iPTMnet Report for P07602 (PSAP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07602 / SAP_HUMAN
Protein Name Prosaposin precursor
Gene Name Name: PSAP
Synonyms:GLBA,SAP1;
Organism Homo sapiens (Human)

PRO ID PR:P07602
DAG View
PRO Name prosaposin (human)
Definition A prosaposin that is encoded in the genome of human.
Short Label hPSAP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07602 (PSAP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
R27 Methylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
T71 Phosphorylation PhosphoSitePlus
N80 N-Glycosylation GlyGen   UniProt 34089345, 19167329, 32125861, ...19159218, 24190977, 23090970, 29391424, 11180632, 2842863, 2110822, 29741879, 8344278
T82 O-Glycosylation GlyGen 28411811, 31637018, 34725712, ...30059200, 29249144, 34019948, 22661428, 35289036, 36240223, 28510447, 28657654
T82 Phosphorylation PhosphoSitePlus
Y89 Phosphorylation PhosphoSitePlus
T93 O-Glycosylation GlyGen 28411811, 31637018, 34725712, ...30059200, 29249144, 34019948, 22661428, 35289036, 36240223, 28510447, 28657654
N101 N-Glycosylation GlyGen   UniProt 19167329, 32125861, 19159218, ...24190977, 23090970, 26791533, 29391424, 11180632, 2842863, 2110822, 29741879, 8344278
S103 O-Glycosylation GlyGen 28411811, 31637018, 34725712, ...30059200, 29249144, 34019948, 22661428, 35289036, 36240223, 28510447, 28657654
S105 O-Glycosylation GlyGen 28411811, 31637018, 34725712, ...30059200, 29249144, 34019948, 22661428, 35289036, 36240223, 28510447, 28657654
S112 Phosphorylation PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
N136 N-Glycosylation GlyGen 29391424
K143 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
T165 Phosphorylation PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
T214 O-Glycosylation GlyGen 28411811, 30237853, 31637018, ...34725712, 30059200, 29249144, 34019948, 22661428, 35289036, 36240223, 28510447, 28657654
N215 N-Glycosylation GlyGen 19167329, 30237853, 24190977, ...23090970, 23345538, 26791533, 29391424, 11180632, 2110822, 29741879, 8344278
S216 O-Glycosylation GlyGen 28411811, 30237853, 31637018, ...34725712, 30059200, 29249144, 34019948, 22661428, 35289036, 36240223, 28510447, 28657654
T217 O-Glycosylation GlyGen 30237853
C230 Methylation IEDB 31844290
C241 Methylation IEDB 31844290
C271 Methylation IEDB 31844290
T281 O-Glycosylation GlyGen 25813380
S289 O-Glycosylation GlyGen 25813380
K290 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
N331 N-Glycosylation GlyGen 24190977
N332 N-Glycosylation GlyGen   UniProt 19167329, 8344278, 19159218, ...24190977, 23090970, 23345538, 11180632, 2110822, 29741879
T334 O-Glycosylation GlyGen 28411811, 31637018, 34725712, ...30059200, 29249144, 34019948, 22661428, 35289036, 36240223, 28510447, 28657654
K336 Ubiquitination PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
T391 O-Glycosylation GlyGen 25813380
T397 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T401 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
K413 Acetylation PhosphoSitePlus
K414 Acetylation PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
Y418 Phosphorylation PhosphoSitePlus
R421 Methylation PhosphoSitePlus
N426 N-Glycosylation GlyGen   UniProt 19167329, 8344278, 19159218, ...24190977, 23090970, 23345538, 11180632, 2110822, 29741879
S427 O-Glycosylation GlyGen 28411811, 31637018, 34725712, ...30059200, 29249144, 34019948, 22661428, 35289036, 36240223, 28510447, 28657654
K429 Ubiquitination PhosphoSitePlus
C440 Methylation IEDB 31844290
K449 Ubiquitination PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus
K487 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N80 N-Glycosylation PRO 11180632, 8344278, 2110822
N101 N-Glycosylation PRO 29741879, 11180632, 26791533, ...8344278, 2110822
N215 N-Glycosylation PRO 8344278, 2110822, 26791533, ...11180632, 23345538, 29741879
N332 N-Glycosylation PRO 2110822, 11180632, 8344278, ...23345538
N426 N-Glycosylation PRO 2110822, 11180632, 8344278, ...23345538


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 R9 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K55 T55 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S103 A103 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T217 I217 Biomuta DOID:4159 / skin cancer [ cosmic ]
S289 Y289 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T391 M391 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y418 F418 Biomuta DOID:4159 / skin cancer [ cosmic ]
R421 C421 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
R421 H421 Biomuta DOID:363 / uterine cancer [ icgc ]
K429 N429 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]