iPTMnet Report for P07237 (P4HB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07237 / PDIA1_HUMAN
Protein Name Protein disulfide-isomerase precursor
Gene Name Name: P4HB
Synonyms:ERBA2L,PDI,PDIA1,PO4DB;
Organism Homo sapiens (Human)

PRO ID PR:P07237
DAG View
PRO Name protein disulfide-isomerase (human)
Definition A protein disulfide-isomerase that is encoded in the genome of human.
Short Label hP4HB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07237 (P4HB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K31 Ubiquitination PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
C53 S-Nitrosylation dbSNO 16724068, 22178444
C56 S-Nitrosylation dbSNO 16724068, 22178444
Y63 Phosphorylation PhosphoSitePlus
K65 Acetylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
R78 Methylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
T85 O-Glycosylation GlyGen 25813380
S88 Phosphorylation PhosphoSitePlus
Y94 Phosphorylation PhosphoSitePlus
R97 Methylation PhosphoSitePlus
Y99 Phosphorylation PhosphoSitePlus
K103 Acetylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
R106 Methylation PhosphoSitePlus
T117 O-Glycosylation GlyGen 25813380
K130 Methylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
T187 O-Glycosylation GlyGen 25813380
S194 O-Glycosylation GlyGen 25813380
K200 Ubiquitination PhosphoSitePlus
K207 Acetylation PhosphoSitePlus
K208 Acetylation PhosphoSitePlus
T221 O-Glycosylation GlyGen 25813380
K222 Ubiquitination PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
Y268 Phosphorylation PhosphoSitePlus
K271 Acetylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
K283 Acetylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
K308 Acetylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
C312 Methylation IEDB 31844290
C312 S-Nitrosylation dbSNO 20140087, 22178444
K326 Ubiquitination PhosphoSitePlus
Y327 Phosphorylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus   UniProt 32149426
T335 Phosphorylation PhosphoSitePlus
R338 Methylation PhosphoSitePlus
C343 Methylation IEDB 31844290
S357 Phosphorylation PhosphoSitePlus   UniProt 26091039, 32149426
K375 Acetylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K385 Acetylation PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
C397 S-Nitrosylation dbSNO 16724068, 22178444
C400 S-Nitrosylation dbSNO 16724068, 22178444
K409 Acetylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus   UniProt 32149426
T428 O-Glycosylation GlyGen 25813380
T428 Phosphorylation PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
T442 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
K444 Acetylation PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
R452 Methylation PhosphoSitePlus
Y457 Phosphorylation PhosphoSitePlus
T462 Phosphorylation PhosphoSitePlus
K467 Acetylation PhosphoSitePlus
K467 Methylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K31 E31 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S32 R32 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
Y63 F63 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R97 C97 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R97 H97 Biomuta DOID:3571 / liver cancer [ cosmic ]
T187 I187 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T221 I221 Biomuta [ cosmic ]
K326 R326 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y327 H327 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S427 L427 Biomuta DOID:363 / uterine cancer [ icgc ]
T428 N428 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T442 I442 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R452 S452 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]