iPTMnet Report for P07202 (TPO)
Protein Information
UniProt AC / UniProt ID | P07202 / PERT_HUMAN |
Protein Name | Thyroid peroxidase precursor |
Gene Name | Name: TPO |
Organism | Homo sapiens (Human) |
PRO ID | PR:P07202 |
PRO Name | thyroid peroxidase (human) |
Definition | A thyroid peroxidase that is encoded in the genome of human. |
Short Label | hTPO |
Category | organism-gene |
P07202 (TPO) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T52 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y55 | Phosphorylation | score1 | PhosphoSitePlus | |||
T57 | Phosphorylation | score1 | PhosphoSitePlus | |||
S97 | Phosphorylation | score1 | PhosphoSitePlus | |||
T561 | Phosphorylation | score1 | PhosphoSitePlus | |||
K879 | Ubiquitination | score1 | PhosphoSitePlus | |||
T891 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y55 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
Y55 | H55 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
T57 | M57 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
S97 | P97 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
S97 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T561 | M561 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1725 / peritoneum cancer [ cosmic ] | |
T891 | P891 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] |