iPTMnet Report for P07195 (LDHB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07195 / LDHB_HUMAN
Protein Name L-lactate dehydrogenase B chain
Gene Name Name: LDHB
Organism Homo sapiens (Human)

PRO ID PR:P07195
DAG View
PRO Name L-lactate dehydrogenase B chain (human)
Definition An L-lactate dehydrogenase B chain that is encoded in the genome of human.
Short Label hLDHB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07195 (LDHB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
K7 Acetylation PhosphoSitePlus   UniProt 19608861
K7 Ubiquitination PhosphoSitePlus
T18 Phosphorylation PhosphoSitePlus
S39 Phosphorylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
S44 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19664994, 19690332
K58 Acetylation PhosphoSitePlus   UniProt 19608861
K58 Ubiquitination PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
T75 Phosphorylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K82 Acetylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
Y84 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
T96 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
K119 Acetylation PhosphoSitePlus   UniProt 19608861
K119 Methylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K156 Acetylation PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
R158 Methylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus   RLIMS-P 31804482
S168 Phosphorylation PhosphoSitePlus
R170 Methylation PhosphoSitePlus
R172 Methylation PhosphoSitePlus
Y173 Phosphorylation PhosphoSitePlus
K229 Acetylation PhosphoSitePlus
K233 Acetylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
Y240 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455, 18083107, 19690332, ...20068231
K244 Acetylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
Y248 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
C294 S-Nitrosylation dbSNO 26338901
T302 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
K308 Acetylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K310 Acetylation PhosphoSitePlus
K310 Sumoylation PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
K318 Acetylation PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K319 Acetylation PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus
K329 Acetylation PhosphoSitePlus   UniProt 19608861
K329 Ubiquitination PhosphoSitePlus
K332 Acetylation PhosphoSitePlus
K332 Sumoylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T18 A18 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K58 N58 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K58 E58 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K60 R60 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K77 I77 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S85 F85 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R158 H158 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R158 C158 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R172 C172 Biomuta DOID:4159 / skin cancer [ cosmic ]
K229 M229 Biomuta DOID:263 / kidney cancer [ cosmic ]
T249 A249 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S269 F269 Biomuta DOID:363 / uterine cancer [ icgc ]
K318 R318 Biomuta DOID:1324 / lung cancer [ cosmic ]