iPTMnet Report for P06899 (H2BC11)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P06899 / H2B1J_HUMAN
Protein Name Histone H2B type 1-J
Gene Name Name: H2BC11
Synonyms:H2BFR;
Organism Homo sapiens (Human)

PRO ID PR:P06899
DAG View
PRO Name histone H2B type 1-J (human)
Definition A histone H2B type 1-J that is encoded in the genome of human.
Short Label hH2BC11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P06899 (H2BC11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Acetylation PRO
K6 Acetylation PRO   UniProt 18552846, 16283522, 16627869
K12 Acetylation PhosphoSitePlus   UniProt 16627869
K13 Acetylation PRO   UniProt 18552846, 16283522, 20693536, ...16627869
S15 Phosphorylation PRO   UniProt 12757711
K16 Acetylation PRO   PhosphoSitePlus   UniProt 16283522, 19883641, 16627869
K17 Acetylation PRO   UniProt 20693536, 16627869
K21 Acetylation PRO   UniProt 18552846, 16627869, 16283522
K24 Acetylation PhosphoSitePlus
K35 Ubiquitination UniProt 21726816
K47 Acetylation PRO 20693536
K47 Methylation UniProt 16627869
S56 Phosphorylation PhosphoSitePlus
K58 Methylation UniProt 16627869
K109 Methylation UniProt 16627869
K121 Acetylation PRO 18552846
K121 Ubiquitination PRO   UniProt 18400894, 16307923, 16627869, ...19575011, 16713563, 18923072, 18832071


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045068 (hHIST1H2BJ/InitMet-/Ac:1) acK13 PRO 16283522, 18552846, 20693536
PR:000045069 (hHIST1H2BJ/InitMet-/Phos:1) pS15 PRO 12757711
PR:000045070 (hHIST1H2BJ/InitMet-/Ac:2) acK21 PRO 16283522, 18552846
PR:000045072 (hHIST1H2BJ/InitMet-/Ubiq:1) ubK121 PRO 16307923, 16713563, 18400894, ...18832071, 18923072, 19575011
PR:000045073 (hHIST1H2BJ/InitMet-/Ac:3) acK17 PRO 20693536
PR:000045074 (hHIST1H2BJ/InitMet-/Ac:4) acK6 PRO 18552846
PR:000045076 (hHIST1H2BJ/InitMet-/Ac:5) acK47 PRO 20693536
PR:000045077 (hHIST1H2BJ/InitMet-/Ac:6) acK121 PRO 18552846
PR:000045078 (hHIST1H2BJ/InitMet-/Ac:7) acK16 PRO 19883641
PR:000047787 (hHIST1H2BJ/InitMet-/N6AcLys+) ac PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K13 E13 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K13 N13 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K16 N16 Biomuta DOID:363 / uterine cancer [ icgc ]
K16 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K47 T47 Biomuta DOID:1324 / lung cancer [ cosmic ]
S56 L56 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
K121 E121 Biomuta DOID:1319 / brain cancer [ icgc ]