iPTMnet Report for P06756 (ITGAV)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P06756 / ITAV_HUMAN
Protein Name Integrin alpha-V precursor
Gene Name Name: ITGAV
Synonyms:MSK8;
Organism Homo sapiens (Human)

PRO ID PR:P06756
DAG View
PRO Name integrin alpha-V (human)
Definition An integrin alpha-V that is encoded in the genome of human.
Short Label hITGAV
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P06756 (ITGAV) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation PhosphoSitePlus
N74 N-Glycosylation GlyGen   UniProt 19704023, 19159218, 24190977, ...23090970, 28117447, 19349973, 29741879
K88 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K149 Sumoylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
T279 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y284 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
N290 N-Glycosylation GlyGen   UniProt 28117447, 19704023
N296 N-Glycosylation GlyGen   UniProt 28117447, 19704023
K360 Ubiquitination PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
Y404 Phosphorylation PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
N488 N-Glycosylation GlyGen   UniProt 29741879, 28117447, 19704023
K514 Ubiquitination PhosphoSitePlus
N554 N-Glycosylation GlyGen   UniProt 28117447, 19704023
K581 Ubiquitination PhosphoSitePlus
T586 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y591 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
N615 N-Glycosylation GlyGen   UniProt 19704023, 19159218, 24190977, ...28117447, 29741879, 12754519
K633 Ubiquitination PhosphoSitePlus
K645 Ubiquitination PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
K701 Ubiquitination PhosphoSitePlus
N704 N-Glycosylation GlyGen   UniProt 19159218, 24190977
S749 Phosphorylation PhosphoSitePlus
T798 Phosphorylation PhosphoSitePlus
N835 N-Glycosylation GlyGen   UniProt 19704023
K864 Ubiquitination PhosphoSitePlus
S866 Phosphorylation PhosphoSitePlus
K873 Ubiquitination PhosphoSitePlus
N874 N-Glycosylation GlyGen   UniProt 23090970, 19349973, 19159218, ...24190977
T876 O-Glycosylation GlyGen 33214551, 34725712, 34019948, ...35289036
K889 Ubiquitination PhosphoSitePlus
N945 N-Glycosylation GlyGen 23090970, 29741879, 24190977
N973 N-Glycosylation GlyGen   UniProt 19704023
N980 N-Glycosylation GlyGen   UniProt 19704023
S1046 Phosphorylation PhosphoSitePlus
T1048 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N74 N-Glycosylation PRO 29741879
Y225 Phosphorylation HPRD 20068231
T279 Phosphorylation HPRD 18669648
Y284 Phosphorylation HPRD 18669648
T586 Phosphorylation HPRD 18669648
Y591 Phosphorylation HPRD 18669648
N615 N-Glycosylation PRO 29741879
S1046 Phosphorylation HPRD 20068231
T1048 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K119 N119 Biomuta DOID:3571 / liver cancer [ cosmic ]
N488 T488 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K645 N645 Biomuta DOID:3571 / liver cancer [ cosmic ]
N704 H704 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S749 I749 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N835 H835 Biomuta DOID:363 / uterine cancer [ icgc ]
K864 N864 Biomuta DOID:1324 / lung cancer [ cosmic ]
S866 L866 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T876 A876 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T876 M876 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
N945 S945 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]