iPTMnet Report for P06396 (GSN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P06396 / GELS_HUMAN
Protein Name Gelsolin precursor
Gene Name Name: GSN
Organism Homo sapiens (Human)

PRO ID PR:P06396
DAG View
PRO Name gelsolin (human)
Definition A gelsolin that is encoded in the genome of human.
Short Label hGSN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P06396 (GSN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S31 O-Glycosylation GlyGen 30459171
S35 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S35 Phosphorylation PhosphoSitePlus
S51 O-Glycosylation GlyGen 35008409, 34019948, 36240223, ...30397120
S51 Phosphorylation PhosphoSitePlus
Y86 Phosphorylation P12931 (SRC) PhosphoSitePlus   UniProt 10210201
K169 Acetylation PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
K245 Acetylation PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
C331 Methylation IEDB 31844290
K338 Acetylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
T386 Phosphorylation PhosphoSitePlus
K390 Acetylation PhosphoSitePlus
R397 Methylation PhosphoSitePlus
T402 O-Glycosylation GlyGen 30459171
S408 O-Glycosylation GlyGen 30459171
S408 Phosphorylation PhosphoSitePlus
Y409 Phosphorylation P12931 (SRC) PhosphoSitePlus   UniProt 10210201
S411 O-Glycosylation GlyGen 30459171
S412 O-Glycosylation GlyGen 30459171
T426 O-Glycosylation GlyGen 30459171
S430 O-Glycosylation GlyGen 30459171
T431 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171
S455 Phosphorylation PhosphoSitePlus
Y465 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor   UniProt 10210201
S473 Phosphorylation PhosphoSitePlus
Y478 Phosphorylation PhosphoSitePlus
Y480 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
Y603 Phosphorylation P12931 (SRC) PhosphoSitePlus   UniProt 10210201
S611 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
K648 Acetylation PhosphoSitePlus
Y651 Phosphorylation P12931 (SRC) PhosphoSitePlus   UniProt 10210201
S654 Phosphorylation PhosphoSitePlus
K661 Acetylation PhosphoSitePlus
C672 Methylation IEDB 31844290
K728 Acetylation PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
Y730 Phosphorylation PhosphoSitePlus
T742 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S261 Phosphorylation HPRD 20068231
T361 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y35 Phosphorylation P41240 (CSK) HPRD 10210201
S210 Phosphorylation HPRD 20068231
T310 Phosphorylation HPRD 20068231
Y358 Phosphorylation P41240 (CSK) HPRD 10210201
Y414 Phosphorylation P41240 (CSK) HPRD 10210201
Y552 Phosphorylation P41240 (CSK) HPRD 10210201
Y600 Phosphorylation P41240 (CSK) HPRD 10210201
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
Y438 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 C11 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S51 C51 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S261 F261 Biomuta DOID:4159 / skin cancer [ cosmic ]
S313 F313 Biomuta DOID:363 / uterine cancer [ icgc ]
K368 E368 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K373 * Biomuta [ cosmic ]
R397 W397 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S411 F411 Biomuta DOID:1324 / lung cancer [ cosmic ]
S611 N611 Biomuta DOID:1612 / breast cancer [ cosmic ]
S636 R636 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y651 * Biomuta DOID:1319 / brain cancer [ cosmic ]
K728 R728 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T742 M742 Biomuta DOID:10534 / stomach cancer [ cosmic ]