iPTMnet Report for P05549 (TFAP2A)
Protein Information
UniProt AC / UniProt ID | P05549 / AP2A_HUMAN |
Protein Name | Transcription factor AP-2-alpha |
Gene Name | Name: TFAP2A Synonyms:AP2TF,TFAP2; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P05549 |
PRO Name | transcription factor AP-2-alpha (human) |
Definition | A transcription factor AP-2-alpha that is encoded in the genome of human. |
Short Label | hTFAP2A |
Category | organism-gene |
P05549 (TFAP2A) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K10 | Sumoylation | score1 | PhosphoSitePlus | |||
K10 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y73 | Phosphorylation | score1 | PhosphoSitePlus | |||
S119 | Phosphorylation | score1 | PhosphoSitePlus | |||
K177 | Sumoylation | score1 | PhosphoSitePlus | |||
K177 | Ubiquitination | score1 | PhosphoSitePlus | |||
S181 | Phosphorylation | score1 | PhosphoSitePlus | |||
K184 | Ubiquitination | score1 | PhosphoSitePlus | |||
S185 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus | 18669648 | ||
S187 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus | 18669648 | ||
K197 | Ubiquitination | score1 | PhosphoSitePlus | |||
S219 | Phosphorylation | score2 | PhosphoSitePlus | 22561688 | ||
S219 | Phosphorylation | P54646 (PRKAA2) | score2 | PhosphoSitePlus | 22561688 | |
S222 | Phosphorylation | score0 | HPRD | 20068231 | ||
S223 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
T224 | Phosphorylation | score0 | HPRD | 20068231 | ||
S225 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus | 18669648, 20068231 | ||
K226 | Ubiquitination | score1 | PhosphoSitePlus | |||
K228 | Ubiquitination | score1 | PhosphoSitePlus | |||
S239 | Phosphorylation | score4 | HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 10037142, 18669648 | ||
S239 | Phosphorylation | P17612 (PRKACA) | score3 | PhosphoSitePlus Signor | 10037142 | |
S258 | Phosphorylation | score3 | neXtProt PhosphoSitePlus RLIMS-P | 18845787 | ||
S258 | Phosphorylation | Q15139 (PRKD1) | score3 | neXtProt PhosphoSitePlus | 18845787 | |
K268 | Ubiquitination | score1 | PhosphoSitePlus | |||
K271 | Ubiquitination | score1 | PhosphoSitePlus | |||
K282 | Ubiquitination | score1 | PhosphoSitePlus | |||
K315 | Ubiquitination | score1 | PhosphoSitePlus | |||
S326 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 18845787 | ||
S326 | Phosphorylation | Q15139 (PRKD1) | score3 | neXtProt PhosphoSitePlus | 18845787 | |
K335 | Ubiquitination | score1 | PhosphoSitePlus | |||
K411 | Ubiquitination | score1 | PhosphoSitePlus | |||
S428 | Phosphorylation | score1 | PhosphoSitePlus | |||
S429 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P Signor | 21777522 | ||
S429 | Phosphorylation | P68400 (CSNK2A1) | score3 | PhosphoSitePlus Signor | 21777522 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S179 | Phosphorylation | score0 | HPRD | 18669648 | ||
S181 | Phosphorylation | score0 | HPRD | 18669648 | ||
S216 | Phosphorylation | score0 | HPRD | 20068231 | ||
S217 | Phosphorylation | score0 | HPRD | 20068231 | ||
T218 | Phosphorylation | score0 | HPRD | 20068231 | ||
S219 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S233 | Phosphorylation | score0 | HPRD | 18669648 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S181 | Phosphorylation | score0 | HPRD | 18669648 | ||
S183 | Phosphorylation | score0 | HPRD | 18669648 | ||
S218 | Phosphorylation | score0 | HPRD | 20068231 | ||
S219 | Phosphorylation | score0 | HPRD | 20068231 | ||
T220 | Phosphorylation | score0 | HPRD | 20068231 | ||
S221 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S235 | Phosphorylation | score0 | HPRD | 18669648 |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | P17302 (GJA1) | S279 | P05549 (TFAP2A) | increased_association | eFIP | 23363606 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T218 | N218 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
T220 | N220 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
S233 | L233 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
S235 | L235 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] |