iPTMnet Report for P05155 (SERPING1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P05155 / IC1_HUMAN
Protein Name Plasma protease C1 inhibitor precursor
Gene Name Name: SERPING1
Synonyms:C1IN,C1NH;
Organism Homo sapiens (Human)

PRO ID PR:P05155
DAG View
PRO Name plasma protease C1 inhibitor (human)
Definition A plasma protease C1 inhibitor that is encoded in the genome of human.
Short Label hSERPING1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05155 (SERPING1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R4 Methylation PhosphoSitePlus
N25 N-Glycosylation GlyGen   UniProt 16335952, 30237853, 16040958, ...14760718, 22171320, 29741879, 3756141, 29671580
T27 O-Glycosylation GlyGen 30459171
S28 O-Glycosylation GlyGen 30459171
S30 O-Glycosylation GlyGen 30459171
S31 O-Glycosylation GlyGen 30459171
S36 O-Glycosylation GlyGen 30237853
T47 O-Glycosylation GlyGen   UniProt 23234360, 22171320, 30237853
T48 O-Glycosylation GlyGen   UniProt 3756141, 23234360, 22171320
S64 O-Glycosylation GlyGen   UniProt 3756141
N69 N-Glycosylation GlyGen   UniProt 16335952, 30237853, 19159218, ...29391424, 29741879, 3756141, 29671580
T71 O-Glycosylation GlyGen   UniProt 3756141
N81 N-Glycosylation GlyGen   UniProt 3756141, 19159218
T83 O-Glycosylation GlyGen   UniProt 3756141
T88 O-Glycosylation GlyGen   UniProt 3756141
T92 O-Glycosylation GlyGen   UniProt 3756141
T96 O-Glycosylation GlyGen   UniProt 3756141
S113 O-Glycosylation GlyGen 30459171
T115 O-Glycosylation GlyGen 30459171
T118 O-Glycosylation GlyGen 30459171
T119 O-Glycosylation GlyGen 30459171
N238 N-Glycosylation GlyGen   UniProt 16335952, 17488724, 30237853, ...19159218, 23090970, 14760718, 29391424, 32125861, 19139490, 24279413, 29741879, 3756141, 29671580
N253 N-Glycosylation GlyGen   UniProt 16335952, 34725484, 24530628, ...29427759, 19159218, 23090970, 14760718, 29391424, 32125861, 19139490, 29741879, 12754519, 29671580, 3756141, 30237853
N272 N-Glycosylation GlyGen 23090970, 24190977
Y294 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
K316 Acetylation PhosphoSitePlus
K321 Acetylation PhosphoSitePlus
N352 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 23090970, ...14760718, 29391424, 19139490, 19838169, 29741879, 3756141
S375 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N25 N-Glycosylation PRO 29671580, 22171320
N69 N-Glycosylation PRO 29671580
N238 N-Glycosylation PRO 24279413, 29671580
N253 N-Glycosylation PRO 29671580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N25 S25 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S31 T31 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S31 C31 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S31 F31 Biomuta DOID:4159 / skin cancer [ cosmic ]
N69 H69 Biomuta DOID:363 / uterine cancer [ icgc ]
S113 Y113 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T119 I119 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y294 C294 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]