iPTMnet Report for P05107 (ITGB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P05107 / ITB2_HUMAN
Protein Name Integrin beta-2 precursor
Gene Name Name: ITGB2
Synonyms:CD18,MFI7;
Organism Homo sapiens (Human)

PRO ID PR:P05107
DAG View
PRO Name integrin beta-2 (human)
Definition An integrin beta-2 that is encoded in the genome of human.
Short Label hITGB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05107 (ITGB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K29 Ubiquitination PhosphoSitePlus
N50 N-Glycosylation GlyGen   UniProt 29741879, 24190977, 19159218, ...19349973
K96 Ubiquitination PhosphoSitePlus
N116 N-Glycosylation GlyGen   UniProt 24385486, 19349973, 20033057, ...24190977
K148 Ubiquitination PhosphoSitePlus
N158 N-Glycosylation GlyGen 24190977
K174 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
C198 Methylation IEDB 31844290
N212 N-Glycosylation GlyGen   UniProt 16335952, 29741879, 24190977, ...19159218, 19349973
N213 N-Glycosylation GlyGen 24190977
N215 N-Glycosylation GlyGen 24190977
C286 Methylation IEDB 31844290
K294 Ubiquitination PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
C386 Methylation IEDB 31844290
K462 Ubiquitination PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
N501 N-Glycosylation GlyGen 24190977
N502 N-Glycosylation GlyGen 24190977
N545 N-Glycosylation GlyGen 24190977
K561 Ubiquitination PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
N642 N-Glycosylation GlyGen   UniProt 29741879, 24385486, 24190977
C647 Methylation IEDB 31844290
K658 Ubiquitination PhosphoSitePlus
C695 Methylation IEDB 31844290
Y735 Phosphorylation P06239 (LCK) PhosphoSitePlus   RLIMS-P 22990843
K740 Acetylation PhosphoSitePlus
K744 Ubiquitination PhosphoSitePlus
S745 Phosphorylation P05771-2 (PRKCB) , P24723 (PRKCH) , Q05655 (PRKCD) , P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11700305
K755 Ubiquitination PhosphoSitePlus
S756 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 11700305
T758 Phosphorylation P24723 (PRKCH) , P05771 (PRKCB) , P17252 (PRKCA) , Q05655 (PRKCD) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16301335, 17384276, 12682249, ...11700305, 18550856
T759 Phosphorylation phospho.ELM   PhosphoSitePlus 12682249
T760 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11700305
K765 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N158 K158 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K174 N174 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K196 N196 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
C198 Y198 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N213 S213 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
N215 K215 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K379 N379 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y735 N735 Biomuta DOID:4159 / skin cancer [ cosmic ]
S756 N756 Biomuta [ cosmic ]
T758 N758 Biomuta DOID:3571 / liver cancer [ cosmic ]
T759 M759 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T759 A759 Biomuta DOID:9256 / colorectal cancer [ cosmic ]