Protein Information

Cytoscape View


UniProt AC / UniProt ID P05067 / A4_HUMAN
Protein Name Amyloid beta A4 protein precursor
Gene Name Name: APP
Synonyms:A4,AD1;
Organism Homo sapiens (Human)

PRO ID PR:P05067
DAG View
PRO Name amyloid beta A4 protein (human)
Definition An amyloid beta A4 protein that is encoded in the genome of human.
Short Label hAPP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05067 (APP) as Substrate



Site PTM Type PTM Enzyme Source PMID
T107 Glycosylation psp
Y115 Phosphorylation psp
S198 Phosphorylation uniprot 8999878
S206 Phosphorylation uniprot 8999878
T352 Glycosylation psp
T353 Glycosylation psp
T366 Glycosylation psp
T367 Glycosylation psp
S370 Glycosylation psp
T371 Glycosylation psp
T381 Phosphorylation psp
T381 Glycosylation psp
S441 Phosphorylation Q8IXL6 (FAM20C) uniprot 26091039
Y497 Phosphorylation uniprot 26091039
T600 Glycosylation psp
T651 Glycosylation psp
T652 Glycosylation psp
S656 Glycosylation psp
T659 Glycosylation psp
T663 Glycosylation psp
S667 Glycosylation psp
K670 Sumoylation psp
S679 Phosphorylation psp
K724 Acetylation psp
K725 Acetylation psp
Y728 Phosphorylation psp
T729 Phosphorylation psp
S730 Phosphorylation psp
T743 Phosphorylation pelm 8764598
T743 Phosphorylation P53779 (MAPK10) uniprot 8131745, 24275569
T743 Phosphorylation P06493 (CDK1) psp 8131745
K751 Ubiquitination psp
Y757 Phosphorylation P06241 (FYN) psp 18089558
T761 Phosphorylation psp
Y762 Phosphorylation hprd   pelm   psp 18083107
K763 Ubiquitination psp
Site PTM Type PTM Enzyme Source PMID
S441 Phosphorylation hprd   psp 18702456, 19664994, 20068231
T743 Phosphorylation P49841 (GSK3B) hprd 8764598, 15178331, 10936190
T743 Phosphorylation Q00535 (CDK5) hprd 8764598, 15178331, 10936190
Y757 Phosphorylation hprd   pelm   uniprot 19901323, 11279131, 11877420, ...18083107


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q99767 (APBA2) S238 P05067 (APP) increasedassociation efip 19222704
Phosphorylation Q99767 (APBA2) S236 P05067 (APP) increasedassociation efip 19222704
Phosphorylation Q99767 (APBA2) S238 P05067 (APP) unknown association efip 19222704