Protein Information

Cytoscape View


UniProt AC / UniProt ID P05067 / A4_HUMAN
Protein Name Amyloid beta A4 protein precursor
Gene Name Name: APP
Synonyms:A4,AD1;
Organism Homo sapiens (Human)

PRO ID PR:P05067
DAG View
PRO Name amyloid beta A4 protein (human)
Definition An amyloid beta A4 protein that is encoded in the genome of human.
Short Label hAPP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P05067 (APP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T107 O-Glycosylation PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus   UniProt 8999878
S206 Phosphorylation PhosphoSitePlus   UniProt 8999878
T352 O-Glycosylation PhosphoSitePlus
T353 O-Glycosylation PhosphoSitePlus
T366 O-Glycosylation PhosphoSitePlus
T367 O-Glycosylation PhosphoSitePlus
S370 O-Glycosylation PhosphoSitePlus
T371 O-Glycosylation PhosphoSitePlus
T381 O-Glycosylation PhosphoSitePlus
T381 Phosphorylation PhosphoSitePlus
S441 Phosphorylation Q8IXL6 (FAM20C) PhosphoSitePlus   UniProt 26091039
R468 Methylation PhosphoSitePlus
Y497 Phosphorylation UniProt 26091039
N542 N-Glycosylation UniProt 16335952
T600 O-Glycosylation PhosphoSitePlus
T633 O-Glycosylation UniProt 21712440, 22576872
T651 O-Glycosylation PhosphoSitePlus   UniProt 21712440, 22576872
T652 O-Glycosylation PhosphoSitePlus   UniProt 21712440, 22576872
S656 O-Glycosylation PhosphoSitePlus   UniProt 21712440
T659 O-Glycosylation PhosphoSitePlus   UniProt 22576872
T663 O-Glycosylation PhosphoSitePlus   UniProt 21712440, 22576872
S667 O-Glycosylation PhosphoSitePlus   UniProt 21712440, 22576872
K670 Sumoylation PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
S697 Phosphorylation PhosphoSitePlus
K724 Acetylation PhosphoSitePlus
K725 Acetylation PhosphoSitePlus
Y728 Phosphorylation PhosphoSitePlus
T729 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
T743 Phosphorylation P53779 (MAPK10) , P45984 (MAPK9) , P06493 (CDK1) , Q00535 (CDK5) , P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 14970211, 8764598, 9109675, ...24610780, 8131745, 15944381, 24275569, 12917434
K751 Ubiquitination PhosphoSitePlus
Y757 Phosphorylation P06241 (FYN) , P04629 (NTRK1) , P00519 (ABL1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 11877420, 18083107, 11279131, ...18089558, 21849536
T761 Phosphorylation PhosphoSitePlus
Y762 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K763 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S441 Phosphorylation HPRD 18702456, 19664994, 20068231
T743 Phosphorylation P49841 (GSK3B) , Q00535 (CDK5) HPRD 8764598, 15178331, 10936190
Y757 Phosphorylation HPRD 19901323, 11279131
Y762 Phosphorylation HPRD 18083107
Site PTM Type PTM Enzyme Score Source PMID
S198 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
T291 O-Glycosylation PhosphoSitePlus
T292 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
Y303 Phosphorylation PhosphoSitePlus
S366 Phosphorylation HPRD 18702456, 19664994, 20068231
T576 O-Glycosylation PhosphoSitePlus
K587 Sumoylation PhosphoSitePlus
K595 Sumoylation PhosphoSitePlus
T654 Phosphorylation O75116 (ROCK2) PhosphoSitePlus 24305806
S655 Phosphorylation PhosphoSitePlus
T668 Phosphorylation P49841 (GSK3B) , Q00535 (CDK5) , P45983 (MAPK8) , P53779 (MAPK10) , Q9Y5Z0 (BACE2) , P45984 (MAPK9) HPRD   neXtProt   PhosphoSitePlus 14970211, 8764598, 16554819, ...10936190, 15944381, 11146006, 15178331
Y682 Phosphorylation HPRD   PhosphoSitePlus 19901323, 11279131
Y687 Phosphorylation HPRD   PhosphoSitePlus 18083107
Site PTM Type PTM Enzyme Score Source PMID
S422 Phosphorylation HPRD 18702456, 19664994, 20068231
T710 Phosphorylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
T724 Phosphorylation Q00535 (CDK5) , P49841 (GSK3B) HPRD   PhosphoSitePlus 8764598, 15178331, 10936190
Y738 Phosphorylation HPRD   PhosphoSitePlus 19901323, 11279131
Y743 Phosphorylation HPRD   PhosphoSitePlus 18083107


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O00213 (APBB1) S610 P05067 (APP) inhibited_association eFIP 26188042