iPTMnet Report for P04908 (H2AC8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04908 / H2A1B_HUMAN
Protein Name Histone H2A type 1-B/E
Gene Name Name: H2AC8
Synonyms:H2AFM;Synonyms:H2AFA;
Organism Homo sapiens (Human)

PRO ID PR:P04908
DAG View
PRO Name histone H2A type 1-B/E (human)
Definition A histone H2A type 1-B/E that is encoded in the genome of human.
Short Label hHIST1H2A[B/E]
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04908 (H2AC8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 15823041, 16457589, 11709551
S2 Phosphorylation PRO   UniProt 15010469, 11709551
K6 Acetylation PRO 17709392
K10 Acetylation PRO 18552846, 12937907
K14 Ubiquitination UniProt 22713238, 22980979
K16 Ubiquitination UniProt 22713238, 22980979
S19 Phosphorylation PhosphoSitePlus
S41 O-Glycosylation GlyGen 27615797
Q105 Methylation UniProt 24352239
K119 Acetylation PhosphoSitePlus
K119 Sumoylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PRO   UniProt 18400894, 16359901, 15386022, ...25470042, 16702407
T121 Phosphorylation HPRD   PRO   UniProt 19965387, 18669648, 24140421, ...15078818
S123 Phosphorylation HPRD 18669648


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044911 (hHIST1H2A[B/E]/InitMet-/Ac:1) acK6 PRO 17709392
PR:000044912 (hHIST1H2A[B/E]/InitMet-/Ubiq:1) ubK120 PRO 15386022, 18400894
PR:000044913 (hHIST1H2A[B/E]/InitMet-/Phos:1) pS2 PRO 15010469
PR:000044915 (hHIST1H2A[B/E]/InitMet-/Ac:2) acK10 PRO 12937907, 18552846
PR:000044920 (hHIST1H2A[B/E]/InitMet-/Phos:2) pT121 PRO 19965387


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S19 F19 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S41 T41 Biomuta DOID:4159 / skin cancer [ cosmic ]
S41 F41 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K120 N120 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]