iPTMnet Report for P04792 (HSPB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04792 / HSPB1_HUMAN
Protein Name Heat shock protein beta-1
Gene Name Name: HSPB1
Synonyms:HSP27,HSP28;
Organism Homo sapiens (Human)

PRO ID PR:P04792
DAG View
PRO Name heat shock protein beta-1 (human)
Definition A heat shock protein beta-1 that is encoded in the genome of human.
Short Label hHSPB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04792 (HSPB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R5 Methylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
R12 Methylation PhosphoSitePlus   UniProt 24129315
S15 Phosphorylation P49137 (MAPKAPK2) , Q05655 (PRKCD) , Q16644 (MAPKAPK3) , P23443 (RPS6KB1) , Q8IW41 (MAPKAPK5) , Q13976-2 (PRKG1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21157431, 21575178, 18720982, ...21999932, 16964243, 17916631, 19562805, 15302935, 30780033, 10383393, 19166925, 21364669, 23950959, 22911792, 17576778, 35945269, 19593530, 15731106, 18691976, 8774846, 23186163, 18212344, 20230923, 15682460, 18440775, 16565220, 8843730, 32506039, 9628874, 20626350, 24275569, 19290620, 15819993, 25699602, 21245386, 23900529, 24699855, 18088087, 24182452, 18767875, 21989268, 20058876, 19007248, 8626550, 19651622, 25569678, 20178975, 11383510, 26887051, 15236192, 17367746, 12096113, 17081983, 32566403, 1332886, 19664994, 29699584, 20600103, 17697330, 25086905, 18669648, 19411251, 32570757, 36173053, 28460458, 20166139, 14717697, 25710824, 33477989, 20068231
R20 Methylation PhosphoSitePlus
Y23 Phosphorylation PhosphoSitePlus
S26 Phosphorylation HPRD   PhosphoSitePlus 20068231
R37 Methylation PhosphoSitePlus
Y54 Phosphorylation PhosphoSitePlus
R56 Methylation PhosphoSitePlus
S65 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17081983, 20068231, ...19007248
Y73 Phosphorylation PhosphoSitePlus
S74 O-Glycosylation GlyGen 23301498, 30620550, 31492838, ...35289036, 22661428, 29237092, 30106436, 34725712, 31637018, 31373491, 22664592, 30059200, 28411811, 30397120, 32574038, 35132862, 22121020, 28657654, 35008409, 33214551, 30379171, 26374642, 18369606, 33723378, 35254053, 34019948, 35083852, 22322011
S74 Phosphorylation PhosphoSitePlus
S78 Phosphorylation P17612 (PRKACA) , P49137 (MAPKAPK2) , Q9UBS0 (RPS6KB2) , P51812 (RPS6KA3) , Q13237 (PRKG2) , P23443 (RPS6KB1) , Q13976-2 (PRKG1) , Q16644 (MAPKAPK3) , Q8IW41 (MAPKAPK5) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21157431, 22647853, 21999932, ...19593530, 12367505, 19290620, 25364415, 35499078, 10383393, 29864522, 21364669, 23900529, 22911792, 17576778, 20497126, 29328466, 8843730, 8774846, 23186163, 18212344, 18688712, 15832340, 18440775, 25446109, 32506039, 25710824, 29729335, 15302935, 17069861, 11912188, 23026841, 20626350, 24275569, 29699584, 32350194, 25699602, 19166925, 9628874, 8307152, 27187380, 24182452, 18767875, 15976317, 20058876, 21575178, 8626550, 24308965, 33119719, 26046355, 14717697, 30780033, 26887051, 19296652, 1730670, 15236192, 21338617, 32545363, 17081983, 20178975, 26867010, 17367746, 23382286, 17949744, 1332886, 14715258, 32566403, 12096113, 25569678, 20600103, 22116673, 17697330, 25086905, 20234090, 19411251, 20640477, 28460458, 11383510, 21245386, 33477989, 23112078, 20068231, 22974980
S82 Phosphorylation P98161 (PKD1) , Q13976-2 (PRKG1) , Q15139 (PRKD1) , Q16644 (MAPKAPK3) , Q9Y243 (AKT3) , Q8IW41 (MAPKAPK5) , Q9UBS0 (RPS6KB2) , P31751 (AKT2) , P31749 (AKT1) , P17612 (PRKACA) , P51812 (RPS6KA3) , P23443 (RPS6KB1) , Q13237 (PRKG2) , P49137 (MAPKAPK2) HPRD   IEDB   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 21157431, 21999932, 16097034, ...10383393, 26046355, 17576778, 18212344, 18440775, 19691289, 29729335, 15302935, 15728188, 17004241, 25699602, 19767773, 23900529, 9628874, 21989268, 17697330, 26105860, 25569678, 11383510, 1730670, 15236192, 17081983, 25710824, 32566403, 19664994, 19664995, 32576196, 28671960, 20166139, 12740362, 28032559, 18578522, 16964243, 19290620, 21364669, 18707149, 23950959, 22911792, 26329039, 18931701, 23852020, 11912188, 17767420, 21245386, 27187380, 31637018, 20058876, 19411251, 29699584, 32296033, 33202651, 20234090, 20600103, 32570757, 23112078, 33477989, 19415658, 20068231, 17924679, 27451881, 12367505, 19562805, 35499078, 15682460, 8843730, 8774846, 23186163, 20661426, 21575178, 32506039, 21338617, 24275569, 30784271, 24882106, 19166925, 8307152, 19651622, 24816797, 26887051, 32387766, 17367746, 20626350, 18669648, 17570131, 19593530, 17349631, 29864522, 20497126, 18691976, 15976317, 27890797, 16565220, 23026841, 24182452, 25086905, 29444163, 24176848, 18767875, 19007248, 8626550, 24308965, 14717697, 20178975, 26867010, 17949744, 1332886, 36173053, 28460458, 18088087
S83 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 15302935, 19007248, ...19691289, 20068231, 16964243
S86 Phosphorylation Q05655 (PRKCD) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 15731106, 23186163, 17081983, ...1332886, 15302935, 27600495, 24275569, 15819993, 16840785, 18212344
R89 Methylation PhosphoSitePlus
T91 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S98 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 24275569
T110 Phosphorylation HPRD 20068231
K112 Ubiquitination PhosphoSitePlus
T113 Phosphorylation HPRD   PhosphoSitePlus 20068231
K114 Sumoylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
T121 Phosphorylation HPRD   PhosphoSitePlus 20068231
K123 Acetylation PhosphoSitePlus   UniProt 19608861
K123 Ubiquitination PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
S135 Phosphorylation HPRD   PhosphoSitePlus 19651622
T139 Phosphorylation PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
T143 Phosphorylation P17612 (PRKACA) , Q13976 (PRKG1) , Q13237 (PRKG2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 11383510, 19593530
T162 Phosphorylation PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
T174 O-Glycosylation GlyGen 23301498, 30620550, 31492838, ...35289036, 22661428, 29237092, 30106436, 34725712, 31637018, 31373491, 22664592, 30059200, 28411811, 30397120, 32574038, 32938750, 35132862, 22121020, 28657654, 35008409, 33214551, 30379171, 26374642, 18369606, 33723378, 35254053, 34019948, 35083852, 22322011
T174 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S176 O-Glycosylation GlyGen 23301498, 30620550, 31492838, ...35289036, 22661428, 29237092, 30106436, 34725712, 31637018, 31373491, 22664592, 30059200, 28411811, 30397120, 32574038, 35132862, 22121020, 28657654, 35008409, 33214551, 30379171, 26374642, 18369606, 33723378, 35254053, 34019948, 35083852, 22322011
S176 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus   UniProt 22394512, 23186163
T180 O-Glycosylation GlyGen 23301498, 30620550, 31492838, ...35289036, 22661428, 29237092, 30106436, 34725712, 31637018, 31373491, 22664592, 30059200, 28411811, 30397120, 32574038, 35132862, 22121020, 28657654, 35008409, 33214551, 30379171, 26374642, 18369606, 33723378, 35254053, 34019948, 35083852, 22322011
T180 Phosphorylation PhosphoSitePlus
T184 O-Glycosylation GlyGen 23301498, 30620550, 31492838, ...35289036, 22661428, 29237092, 30106436, 34725712, 31637018, 31373491, 22664592, 30059200, 28411811, 30397120, 32574038, 32938750, 35132862, 22121020, 28657654, 35008409, 33214551, 30379171, 26374642, 18369606, 33723378, 35254053, 34019948, 35083852, 22322011
T184 Phosphorylation PhosphoSitePlus
S187 O-Glycosylation GlyGen 23301498, 34725712, 30620550, ...31492838, 35289036, 22661428, 29237092, 30106436, 30397120, 31637018, 31373491, 22664592, 30059200, 28411811, 34846842, 32574038, 35132862, 22121020, 28657654, 35008409, 33214551, 30379171, 26374642, 18369606, 33723378, 35254053, 34019948, 35083852, 22322011
S187 Phosphorylation PhosphoSitePlus
K198 Sumoylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
S199 O-Glycosylation GlyGen 23301498, 30620550, 31492838, ...35289036, 22661428, 29237092, 30106436, 34725712, 31637018, 31373491, 22664592, 30059200, 28411811, 30397120, 32574038, 35132862, 22121020, 28657654, 35008409, 33214551, 30379171, 26374642, 18369606, 33723378, 35254053, 34019948, 35083852, 22322011
S199 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 19007248, ...19691289, 19651622, 18669648, 24275569, 20166139, 20068231
T202 Phosphorylation PhosphoSitePlus
K205 Acetylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047918 (hHSPB1/Phos:2) pS15,pS78,pS82 PRO
PR:000047919 (hHSPB1/Phos:3) pS78,pS82 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04792 (HSPB1) S78 P99999 (CYCS) unknown eFIP 22974980


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R5 C5 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S9 * Biomuta DOID:4159 / skin cancer [ cosmic ]
R20 C20 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y23 S23 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T164 A164 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K171 N171 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]