iPTMnet Report for P04632 (CAPNS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04632 / CPNS1_HUMAN
Protein Name Calpain small subunit 1
Gene Name Name: CAPNS1
Synonyms:CAPN4,CAPNS;
Organism Homo sapiens (Human)

PRO ID PR:P04632
DAG View
PRO Name calpain small subunit 1 (human)
Definition A calpain small subunit 1 that is encoded in the genome of human.
Short Label hCAPNS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04632 (CAPNS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22223895, 25944712
S6 Phosphorylation PhosphoSitePlus   UniProt 23186163
K9 Acetylation PhosphoSitePlus
K9 Methylation PhosphoSitePlus
K9 Sumoylation PhosphoSitePlus
S34 O-Glycosylation GlyGen 23301498, 34019948, 34725712, ...29351928, 35254053
S34 Phosphorylation HPRD 20068231
T57 O-Glycosylation GlyGen 23301498, 34019948, 34725712, ...29351928, 35254053
S67 Phosphorylation PhosphoSitePlus
S70 Phosphorylation PhosphoSitePlus
T85 O-Glycosylation GlyGen 23301498, 34019948, 34725712, ...29351928, 35254053
T85 Phosphorylation PhosphoSitePlus
Y87 Phosphorylation PhosphoSitePlus
S88 Phosphorylation HPRD   PhosphoSitePlus 20166139
R99 Methylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
C144 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
S146 Phosphorylation PhosphoSitePlus
S153 O-Glycosylation GlyGen 25813380
S153 Phosphorylation PhosphoSitePlus
T156 Phosphorylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
K165 Acetylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
Y178 Phosphorylation PhosphoSitePlus
K179 Acetylation PhosphoSitePlus   UniProt 19608861
K179 Ubiquitination PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K9 Q9 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S34 N34 Biomuta DOID:4362 / cervical cancer [ icgc ]
S88 F88 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R99 W99 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]