Protein Information

Cytoscape View


UniProt AC / UniProt ID P04626 / ERBB2_HUMAN
Protein Name Receptor tyrosine-protein kinase erbB-2 precursor
Gene Name Name: ERBB2
Synonyms:HER2,MLN19,NEU,NGL;
Organism Homo sapiens (Human)

PRO ID PR:P04626
DAG View
PRO Name receptor tyrosine-protein kinase erbB-2 (human)
Definition A receptor tyrosine-protein kinase erbB-2 that is encoded in the genome of human.
Short Label hERBB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04626 (ERBB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
N68 N-Glycosylation UniProt 20696930
K150 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus   UniProt 23186163
S196 Phosphorylation PhosphoSitePlus
N259 N-Glycosylation UniProt 19299620, 15093539, 20696930
N530 N-Glycosylation UniProt 19299620, 15093539
N571 N-Glycosylation UniProt 20696930
T686 Phosphorylation P17252 (PRKCA) , Q13237 (PRKG2) , P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 26676300, 18799465, 23254288, ...9855018, 8702975
T701 Phosphorylation PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
K724 Ubiquitination PhosphoSitePlus
S728 Phosphorylation PhosphoSitePlus
T733 Phosphorylation PhosphoSitePlus
Y735 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K736 Ubiquitination PhosphoSitePlus
K747 Ubiquitination PhosphoSitePlus
K753 Ubiquitination PhosphoSitePlus
T759 Phosphorylation PhosphoSitePlus
Y772 Phosphorylation PhosphoSitePlus
S819 Phosphorylation PhosphoSitePlus
K860 Ubiquitination PhosphoSitePlus
T875 Phosphorylation PhosphoSitePlus
Y877 Phosphorylation P04626 (ERBB2) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 19289058, 20332114, 22676470, ...23212450, 20818175, 23843458, 17237269, 15163624, 22549178, 25596742, 25853726, 25346782, 16785428, 23318431, 15300809, 19760502, 15695410
K887 Ubiquitination PhosphoSitePlus
T900 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 26143491
Y923 Phosphorylation PhosphoSitePlus
T948 Phosphorylation PhosphoSitePlus
S974 Phosphorylation PhosphoSitePlus
S977 Phosphorylation PhosphoSitePlus
S998 Phosphorylation PhosphoSitePlus
S1002 Phosphorylation PhosphoSitePlus
T1003 Phosphorylation PhosphoSitePlus
Y1005 Phosphorylation PhosphoSitePlus
S1007 Phosphorylation PhosphoSitePlus
Y1023 Phosphorylation P04626 (ERBB2) neXtProt   PRO   PhosphoSitePlus   Signor 1706616
S1049 Phosphorylation PhosphoSitePlus
S1050 Phosphorylation PhosphoSitePlus
S1051 Phosphorylation PhosphoSitePlus
T1052 Phosphorylation PhosphoSitePlus
S1054 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...18669648, 24275569
T1060 Phosphorylation PhosphoSitePlus
S1066 Phosphorylation PhosphoSitePlus
S1073 Phosphorylation PhosphoSitePlus   RLIMS-P 24263233
S1078 Phosphorylation PhosphoSitePlus
S1083 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1100 Phosphorylation PhosphoSitePlus
T1103 Phosphorylation PhosphoSitePlus
S1107 Phosphorylation PhosphoSitePlus   UniProt 20068231
Y1112 Phosphorylation P04626 (ERBB2) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15210733, 15163624, 23027125, ...27050377, 1706616, 10910043, 25081058, 27134172
S1113 Phosphorylation RLIMS-P 11330837, 23254288
S1122 Phosphorylation PhosphoSitePlus
T1124 Phosphorylation PhosphoSitePlus
Y1127 Phosphorylation PhosphoSitePlus
T1132 Phosphorylation PhosphoSitePlus
S1134 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y1139 Phosphorylation P04626 (ERBB2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 15210733, 9079677, 10372802, ...16371159, 23027125, 1706616, 16624867, 21966491, 11500516, 27134172
S1151 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
T1166 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1172 Phosphorylation Q9UQM7 (CAMK2A) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 10347170, 8700533
S1174 Phosphorylation Q00535 (CDK5) neXtProt   PhosphoSitePlus 12824184, 17145757
Y1196 Phosphorylation P04626 (ERBB2) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 27531070, 24810047, 15156151, ...21966491, 25081058, 26143491, 11500516, 27134172
T1198 Phosphorylation PhosphoSitePlus
S1214 Phosphorylation PhosphoSitePlus
Y1221 Phosphorylation P04626 (ERBB2) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 22561705, 26490994, 19239686, ...25193864, 25792810, 19754954, 23254288, 21966491, 18682844, 21364123, 25889497, 1706616, 21791570, 26625311, 26143491, 11500516
Y1222 Phosphorylation P04626 (ERBB2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 22561705, 26490994, 19239686, ...11953857, 25792810, 10372802, 19754954, 15156151, 23254288, 21966491, 18682844, 21364123, 25889497, 1706616, 21791570, 26625311, 11500516, 26143491, 9637788, 25193864
S1235 Phosphorylation PhosphoSitePlus
T1236 Phosphorylation PhosphoSitePlus
T1240 Phosphorylation PhosphoSitePlus
T1242 Phosphorylation PhosphoSitePlus
Y1248 Phosphorylation P00533 (EGFR) , P04626 (ERBB2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15210733, 26114632, 20201928, ...21712485, 24801752, 15163624, 19491269, 24835103, 27356767, 15300809, 12748185, 27416801, 19082476, 22892392, 17525746, 18687633, 19094209, 21209853, 16414259, 9334404, 16624867, 20010870, 24278211, 11500516, 17206861, 25344208, 12354693, 23212450, 20386540, 17554007, 12386815, 28243327, 28020647, 21034468, 18264744, 10585492, 27134172, 9637788, 25686822, 17081983, 18945363, 7624146, 25773930, 1706616, 17490486, 15695410, 25081058, 26143491, 18320059, 27345410
Site PTM Type PTM Enzyme Score Source PMID
Y735 Phosphorylation HPRD 16729043
Y877 Phosphorylation HPRD 16785428
Y923 Phosphorylation HPRD 16729043
S998 Phosphorylation HPRD 20068231
Y1005 Phosphorylation HPRD 16729043
Y1023 Phosphorylation P04626 (ERBB2) HPRD 11500516, 16729043, 1706616
S1054 Phosphorylation HPRD 18691976, 18669648, 19664994, ...20068231
S1107 Phosphorylation HPRD 20068231
S1134 Phosphorylation HPRD 18669648
Y1139 Phosphorylation P04626 (ERBB2) HPRD 10372802, 16729043, 1706616
S1151 Phosphorylation HPRD 18669648
Y1196 Phosphorylation HPRD 11500516, 16729043
Y1221 Phosphorylation P04626 (ERBB2) HPRD 11500516, 1706616
Y1222 Phosphorylation P04626 (ERBB2) HPRD 10372802, 16729043, 1706616
Y1248 Phosphorylation P00533 (EGFR) , P04626 (ERBB2) HPRD 1706616, 17389395, 17426253, ...12354693
Site PTM Type PTM Enzyme Score Source PMID
S968 Phosphorylation HPRD 20068231
Y993 Phosphorylation P04626 (ERBB2) HPRD 11500516, 1706616
S1024 Phosphorylation HPRD 18691976, 18669648, 19664994, ...20068231
S1077 Phosphorylation HPRD 20068231
S1104 Phosphorylation HPRD 18669648
Y1109 Phosphorylation P04626 (ERBB2) HPRD 10372802, 1706616
S1121 Phosphorylation HPRD 18669648
Y1166 Phosphorylation HPRD 11500516
Y1191 Phosphorylation P04626 (ERBB2) HPRD 11500516, 1706616
Y1192 Phosphorylation P04626 (ERBB2) HPRD 10372802, 1706616
Y1218 Phosphorylation P04626 (ERBB2) , P00533 (EGFR) HPRD 11500516, 17426253, 17389395


P04626 (ERBB2) as PTM Enzyme



Substrate Site Score Source PMID
O43157 (PLXNB1) Y1708 PhosphoSitePlus 19805522
O43157 (PLXNB1) Y1732 PhosphoSitePlus 19805522
P00533-1 (EGFR) Y1069 HPRD 17016520, 18691976, 17389395, ...9363897, 18669648, 16799092, 10635327
P04626 (ERBB2) Y877 PhosphoSitePlus 16785428
P04626-5 (ERBB2) Y993 HPRD 11500516, 1706616
P04626 (ERBB2) Y1023 HPRD   neXtProt   PhosphoSitePlus   Signor 11500516, 1706616, 16729043
P04626-5 (ERBB2) Y1109 HPRD 10372802, 1706616
P04626 (ERBB2) Y1112 PhosphoSitePlus   Signor 1706616
P04626-1 (ERBB2) Y1139 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 10372802, 16729043, 1706616, ...11500516
P04626-5 (ERBB2) Y1191 HPRD 11500516, 1706616
P04626-5 (ERBB2) Y1192 HPRD 10372802, 1706616
P04626 (ERBB2) Y1196 phospho.ELM   PhosphoSitePlus   Signor 11500516, 15156151
P04626-5 (ERBB2) Y1218 HPRD 11500516, 17426253, 17389395
P04626-1 (ERBB2) Y1221 HPRD   phospho.ELM   PhosphoSitePlus   Signor 11500516, 1706616
P04626 (ERBB2) Y1222 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10372802, 9637788, 15156151, ...1706616, 11500516, 16729043
P04626 (ERBB2) Y1248 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 9637788, 17389395, 17081983, ...17426253, 1706616, 11500516, 12354693
P06493 (CDK1) Y15 neXtProt   PhosphoSitePlus   Signor 12049736
P35222 (CTNNB1) Y654 neXtProt   PhosphoSitePlus 14517306
Q96N67 (DOCK7) Y1257 PhosphoSitePlus   Signor 18426980
Q9BXH1 (BBC3) Y58 PhosphoSitePlus 24236056
Q9BXH1 (BBC3) Y152 PhosphoSitePlus 24236056
Q9BXH1 (BBC3) Y172 PhosphoSitePlus 24236056


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047318 (hERBB2/SigPep-/Phos:2) pY1023,pY1112,pY1139,pY1196,pY1221,pY1222,pY1248 PRO
PR:000047319 (hERBB2/SigPep-/Phos:3) pY1023,pY1139,pY1196,pY1221,pY1222,pY1248 PRO
PR:000047320 (hERBB2/SigPep-/Phos:4) pY877 PRO
PR:000047321 (hERBB2/SigPep-/Phos:5) pY877,pY1023,pY1112,pY1139,pY1196,pY1221,pY1222,pY1248 PRO
PR:000047322 (hERBB2/SigPep-/Phos:6) pY877,pY1023,pY1139,pY1196,pY1221,pY1222,pY1248 PRO
PR:000047323 (hERBB2/SigPep-/PhosTyr+) p PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04626 (ERBB2) Y1248 P00533 (EGFR) unknown eFIP 15163624
Phosphorylation P04626 (ERBB2) Y1112 P00533 (EGFR) unknown eFIP 15163624
Phosphorylation P04626 (ERBB2) Y877 P00533 (EGFR) unknown eFIP 15163624