Protein Information

Cytoscape View


UniProt AC / UniProt ID P04626 / ERBB2_HUMAN
Protein Name Receptor tyrosine-protein kinase erbB-2 precursor
Gene Name Name: ERBB2
Synonyms:HER2,MLN19,NEU,NGL;
Organism Homo sapiens (Human)

PRO ID PR:P04626
DAG View
PRO Name receptor tyrosine-protein kinase erbB-2 (human)
Definition A receptor tyrosine-protein kinase erbB-2 that is encoded in the genome of human.
Short Label hERBB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04626 (ERBB2) as Substrate



Site PTM Type PTM Enzyme Source PMID
K150 Ubiquitination psp
K175 Ubiquitination psp
T182 Phosphorylation psp
T686 Phosphorylation P17252 (PRKCA) psp 9855018
T686 Phosphorylation pelm   rlimsp 18799465, 8702975, 9855018
T686 Phosphorylation P17612 (PRKACA) psp 18799465
T686 Phosphorylation Q13237 (PRKG2) psp 26676300
T701 Phosphorylation psp
S703 Phosphorylation psp
K724 Ubiquitination psp
S728 Phosphorylation psp
T733 Phosphorylation psp
Y735 Phosphorylation hprd   pelm   psp 18083107, 16729043
K736 Ubiquitination psp
K747 Ubiquitination psp
K753 Ubiquitination psp
Y772 Phosphorylation psp
K860 Ubiquitination psp
T875 Phosphorylation psp
Y877 Phosphorylation P04626 (ERBB2) psp 16785428
Y877 Phosphorylation hprd   pelm   rlimsp 19289058, 20332114, 23212450, ...20818175, 23843458, 17237269, 15163624, 15695410, 16785428, 23318431, 15300809, 19760502
K887 Ubiquitination psp
T900 Phosphorylation Q13131 (PRKAA1) psp 26143491
T948 Phosphorylation psp
S998 Phosphorylation hprd   psp 20068231
S1002 Phosphorylation psp
T1003 Phosphorylation psp
Y1005 Phosphorylation hprd   psp 16729043
S1007 Phosphorylation psp
Y1023 Phosphorylation P04626 (ERBB2) hprd   psp 11500516, 1706616, 16729043
S1049 Phosphorylation psp
S1050 Phosphorylation psp
S1051 Phosphorylation psp
T1052 Phosphorylation psp
S1054 Phosphorylation hprd   pelm   psp   uniprot 18691976, 21406692, 19664994, ...18669648, 24275569, 20068231
S1066 Phosphorylation psp
S1078 Phosphorylation psp
S1083 Phosphorylation psp
S1100 Phosphorylation psp
T1103 Phosphorylation psp
S1107 Phosphorylation hprd   psp   uniprot 20068231
Y1112 Phosphorylation pelm   rlimsp 15163624, 10910043
Y1112 Phosphorylation P04626 (ERBB2) psp 1706616
S1113 Phosphorylation rlimsp 11330837
S1122 Phosphorylation psp
T1124 Phosphorylation psp
Y1127 Phosphorylation psp
T1132 Phosphorylation psp
S1134 Phosphorylation hprd   pelm   psp 18669648
Y1139 Phosphorylation P04626 (ERBB2) hprd   pelm   psp   rlimsp 11500516, 1706616, 16729043, ...10372802
Y1139 Phosphorylation rlimsp 21966491, 9079677
S1151 Phosphorylation hprd   pelm   psp   uniprot 18669648, 24275569
T1166 Phosphorylation psp
T1172 Phosphorylation pelm   psp   rlimsp 10347170, 8700533
S1174 Phosphorylation psp
Y1196 Phosphorylation hprd   rlimsp 11500516, 16729043, 21966491
Y1196 Phosphorylation P04626 (ERBB2) pelm   psp 11500516, 15156151
T1198 Phosphorylation psp
S1214 Phosphorylation psp
Y1221 Phosphorylation rlimsp 21364123, 22561705, 19239686
Y1221 Phosphorylation P04626 (ERBB2) hprd   pelm   psp 11500516, 1706616
Y1222 Phosphorylation rlimsp 21364123, 22561705, 19239686
Y1222 Phosphorylation P04626 (ERBB2) hprd   pelm   psp   rlimsp 10372802, 9637788, 15156151, ...1706616, 11500516, 16729043
S1235 Phosphorylation psp
T1236 Phosphorylation psp
T1240 Phosphorylation psp
T1242 Phosphorylation psp
Y1248 Phosphorylation hprd   pelm   rlimsp 20201928, 15163624, 17389395, ...19491269, 24835103, 15300809, 12748185, 17525746, 18687633, 17426253, 16414259, 9334404, 12354693, 23212450, 12386815, 18264744, 20010870, 17081983, 25773930, 1706616, 15695410, 18320059
Y1248 Phosphorylation P04626 (ERBB2) hprd   pelm   psp   rlimsp   uniprot 9637788, 17389395, 17081983, ...17554007, 17426253, 7624146, 1706616, 11500516, 12354693
Site PTM Type PTM Enzyme Source PMID
Y923 Phosphorylation hprd   psp 16729043
Y1248 Phosphorylation P00533 (EGFR) hprd 1706616, 17389395, 17426253, ...12354693


P04626 (ERBB2) as PTM Enzyme



Substrate Site Source PMID
O43157 (PLXNB1) Y1708 psp 19805522
O43157 (PLXNB1) Y1732 psp 19805522
P00533-1 (EGFR) Y1069 hprd 17016520, 18691976, 17389395, ...9363897, 18669648, 16799092, 10635327
P04626 (ERBB2) Y877 psp 16785428
P04626 (ERBB2) Y1023 hprd   psp 11500516, 1706616, 16729043
P04626 (ERBB2) Y1112 psp 1706616
P04626 (ERBB2) Y1139 hprd   pelm   psp   rlimsp 11500516, 1706616, 16729043, ...10372802
P04626 (ERBB2) Y1196 pelm   psp 11500516, 15156151
P04626 (ERBB2) Y1221 hprd   pelm   psp 11500516, 1706616
P04626 (ERBB2) Y1222 hprd   pelm   psp   rlimsp 10372802, 9637788, 15156151, ...1706616, 11500516, 16729043
P04626 (ERBB2) Y1248 hprd   pelm   psp   rlimsp   uniprot 9637788, 17389395, 17081983, ...17554007, 17426253, 7624146, 1706616, 11500516, 12354693
P06493 (CDK1) Y15 psp 12049736
P35222-1 (CTNNB1) Y654 pro   psp 14517306, 23640056
Q96N67 (DOCK7) Y1257 psp 18426980
Q9BXH1 (BBC3) Y58 psp 24236056
Q9BXH1 (BBC3) Y152 psp 24236056
Q9BXH1 (BBC3) Y172 psp 24236056


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04626 (ERBB2) Y877 P00533 (EGFR) unknown association efip 15163624
Phosphorylation P04626 (ERBB2) Y1112 P00533 (EGFR) unknown association efip 15163624
Phosphorylation P04626 (ERBB2) Y1248 P00533 (EGFR) unknown association efip 15163624