iPTMnet Report for P04350 (TUBB4A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04350 / TBB4A_HUMAN
Protein Name Tubulin beta-4A chain
Gene Name Name: TUBB4A
Synonyms:TUBB4,TUBB5;
Organism Homo sapiens (Human)

PRO ID PR:P04350
DAG View
PRO Name tubulin beta-4A chain (human)
Definition A tubulin beta-4A chain that is encoded in the genome of human.
Short Label hTUBB4A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04350 (TUBB4A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R2 Methylation PhosphoSitePlus
C12 S-Nitrosylation dbSNO 22126794, 21278135
K19 Acetylation PhosphoSitePlus
K19 Methylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
Y36 Phosphorylation PRO   PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
T55 Phosphorylation PhosphoSitePlus
Y59 Phosphorylation PhosphoSitePlus
T72 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
K103 Acetylation PhosphoSitePlus
K103 Sumoylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
T143 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
T149 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus   UniProt 16371510
K174 Ubiquitination PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus
T199 Phosphorylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
Y208 Phosphorylation PhosphoSitePlus
C211 Methylation IEDB 31844290
K216 Acetylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
T218 Phosphorylation PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus
T221 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
C239 S-Nitrosylation dbSNO 21278135
K252 Acetylation PhosphoSitePlus
K252 Sumoylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
R276 Methylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus
T290 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16565220
K297 Acetylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
C303 Methylation IEDB 31844290
C303 S-Nitrosylation dbSNO 21278135
Y310 Phosphorylation PhosphoSitePlus
T312 Phosphorylation PhosphoSitePlus
R318 Methylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
S332 Phosphorylation HPRD   PhosphoSitePlus 18491316
S335 Phosphorylation HPRD   PhosphoSitePlus 18491316
K336 Ubiquitination PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
Y340 Phosphorylation PhosphoSitePlus
K350 Sumoylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
T351 Phosphorylation PhosphoSitePlus
C354 S-Nitrosylation dbSNO 21278135
K362 Ubiquitination PhosphoSitePlus
T366 Phosphorylation PRO   PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
K379 Acetylation PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
T386 Phosphorylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
T399 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036905 (hTUBB4A/Phos:1) pY36,pT366 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T55 I55 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S75 Y75 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S78 Y78 Biomuta DOID:363 / uterine cancer [ icgc ]
T143 M143 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S145 Y145 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T149 M149 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ]
S172 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y183 C183 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y208 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K216 E216 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y222 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T274 S274 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R276 Q276 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S278 I278 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y281 * Biomuta DOID:363 / uterine cancer [ cosmic ]
T285 K285 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T285 M285 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
R318 W318 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R318 Q318 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S322 F322 Biomuta DOID:4159 / skin cancer [ cosmic ]
S332 N332 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K336 R336 Biomuta DOID:4159 / skin cancer [ cosmic ]
T351 M351 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K362 N362 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T386 M386 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K392 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T399 M399 Biomuta DOID:9256 / colorectal cancer [ cosmic ]