iPTMnet Report for P04183 (TK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04183 / KITH_HUMAN
Protein Name Thymidine kinase, cytosolic
Gene Name Name: TK1
Organism Homo sapiens (Human)

PRO ID PR:P04183
DAG View
PRO Name thymidine kinase, cytosolic (human)
Definition A thymidine kinase, cytosolic that is encoded in the genome of human.
Short Label hTK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04183 (TK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19369195, 22814378, 22223895, ...20068231
S2 Phosphorylation PhosphoSitePlus   UniProt 23186163
T8 Phosphorylation PhosphoSitePlus
S13 Phosphorylation P06493 (CDK1) , P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19413330, 25003822, 12435275, ...23186163, 14697231, 9575153, 20068231
S15 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19651622, 20068231
K16 Ubiquitination PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
K32 Acetylation PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
C50 Methylation IEDB 31844290
Y55 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
R70 Methylation PhosphoSitePlus
C79 Methylation IEDB 31844290
K131 Ubiquitination PhosphoSitePlus
K164 Acetylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
Y181 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K220 Acetylation PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
C230 S-Nitrosylation dbSNO 26338901
S231 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 25003822, 16964243, ...18767875, 19664995, 17322306, 18669648, 19415658, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S13 F13 Biomuta DOID:1324 / lung cancer [ cosmic ]
R70 L70 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
C79 Y79 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y181 H181 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S183 C183 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K211 T211 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
C230 Y230 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S231 R231 Biomuta DOID:3571 / liver cancer [ cosmic ]