iPTMnet Report for P04075 (ALDOA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04075 / ALDOA_HUMAN
Protein Name Fructose-bisphosphate aldolase A
Gene Name Name: ALDOA
Synonyms:ALDA;
Organism Homo sapiens (Human)

PRO ID PR:P04075
DAG View
PRO Name fructose-bisphosphate aldolase A (human)
Definition A fructose-bisphosphate aldolase A that is encoded in the genome of human.
Short Label hALDOA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04075 (ALDOA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y3 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107, 20068231
Y5 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107, 20068231
T9 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 19664994, 23186163
K13 Acetylation PhosphoSitePlus
K13 Ubiquitination PhosphoSitePlus
K14 Acetylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
S17 Phosphorylation HPRD   PhosphoSitePlus 20068231
K28 Ubiquitination PhosphoSitePlus
S36 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 18767875, ...20058876, 17322306, 20166139, 19690332, 20068231
T37 Phosphorylation HPRD   PhosphoSitePlus 17322306, 19413330, 20058876, ...20166139
S39 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 20058876, 18702456, ...19664994, 18452278, 19651622, 18510355, 18669648, 24275569, 18767875, 20166139, 23186163, 19690332, 20068231
K42 Acetylation PhosphoSitePlus   UniProt 19608861
K42 Sumoylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
S46 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18767875, 19651622, 24275569, 20068231
T49 Phosphorylation PhosphoSitePlus
T52 Phosphorylation PhosphoSitePlus
R56 Methylation PhosphoSitePlus
T65 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16097034, 20068231
R69 Methylation PhosphoSitePlus
C73 S-Nitrosylation dbSNO 20140087, 22178444
K87 Ubiquitination PhosphoSitePlus
K99 Methylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
K101 Methylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K108 Acetylation PhosphoSitePlus   UniProt 19608861
K108 Sumoylation PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K111 Acetylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
R134 Methylation PhosphoSitePlus
C135 Methylation IEDB 31844290
Y138 Phosphorylation PhosphoSitePlus
K139 Acetylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K147 Acetylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K153 Acetylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
T158 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
Y174 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
K200 Acetylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
C202 Methylation IEDB 31844290
Y204 Phosphorylation HPRD   PhosphoSitePlus 15592455
T206 Phosphorylation PhosphoSitePlus
K208 Acetylation PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
Y214 Phosphorylation PhosphoSitePlus
K215 Methylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
A216 Methylation IEDB 32357974
S218 Phosphorylation PhosphoSitePlus
Y223 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
T227 Phosphorylation PhosphoSitePlus
K230 Acetylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
T235 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
C240 S-Nitrosylation dbSNO 20140087, 22178444
T241 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
T269 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus   UniProt 24275569
S276 Phosphorylation PhosphoSitePlus
C290 Methylation IEDB 31844290
K294 Acetylation PhosphoSitePlus
K294 Methylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
T299 Phosphorylation PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
K312 Acetylation PhosphoSitePlus
K312 Methylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K322 Acetylation PhosphoSitePlus
K322 Methylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
Y328 Phosphorylation PhosphoSitePlus
K330 Acetylation PhosphoSitePlus   UniProt 19608861
K330 Ubiquitination PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
C339 Methylation IEDB 31844290
C339 S-Nitrosylation dbSNO 19483679, 2212679, 22178444, ...20140087
K342 Acetylation PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
Y343 Phosphorylation PhosphoSitePlus
T344 O-Glycosylation GlyGen 16408927, 14985449, 35138101, ...30397120, 33214551, 34725712, 34019948, 30620550, 35132862, 35083852, 31492838, 20305658, 32119511, 35254053
T344 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S354 O-Glycosylation GlyGen 16408927, 14985449, 32938750, ...35138101, 30397120, 33214551, 34725712, 34019948, 30620550, 35132862, 35083852, 31492838, 20305658, 32119511, 35254053
S354 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
S356 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
S360 Phosphorylation PhosphoSitePlus
Y364 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y3 Phosphorylation HPRD 18083107, 20068231
Y5 Phosphorylation HPRD 18083107, 20068231
T9 Phosphorylation HPRD 19413330, 19664994
S17 Phosphorylation HPRD 20068231
S36 Phosphorylation HPRD 19413330, 18767875, 20058876, ...17322306, 20166139, 20068231
T37 Phosphorylation HPRD 17322306, 19413330, 20058876, ...20166139
S39 Phosphorylation HPRD 20058876, 18702456, 19664994, ...18452278, 19651622, 18510355, 18669648, 18767875, 20166139, 20068231
S46 Phosphorylation HPRD 19651622, 18767875, 17081983, ...20068231
T65 Phosphorylation HPRD 20068231
Y204 Phosphorylation HPRD 15592455
Y223 Phosphorylation HPRD 18083107
T235 Phosphorylation HPRD 17287340
T241 Phosphorylation HPRD 17287340
S354 Phosphorylation HPRD 17287340
S356 Phosphorylation HPRD 17287340


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R56 W56 Biomuta DOID:4159 / skin cancer [ cosmic ]
R69 S69 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K101 M101 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K108 R108 Biomuta DOID:363 / uterine cancer [ icgc ]
K111 E111 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S160 L160 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S176 N176 Biomuta DOID:4159 / skin cancer [ cosmic ]
K200 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C202 * Biomuta DOID:1324 / lung cancer [ cosmic ]
Y204 C204 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S218 C218 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T269 A269 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K318 E318 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T344 N344 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T344 A344 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S354 R354 Biomuta DOID:1324 / lung cancer [ cosmic ]
S354 T354 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S354 I354 Biomuta DOID:1324 / lung cancer [ cosmic ]