iPTMnet Report for P04070 (PROC)
Protein Information
UniProt AC / UniProt ID | P04070 / PROC_HUMAN |
Protein Name | Vitamin K-dependent protein C precursor |
Gene Name | Name: PROC |
Organism | Homo sapiens (Human) |
PRO ID | PR:P04070 |
PRO Name | vitamin K-dependent protein C (human) |
Definition | A vitamin K-dependent protein C that is encoded in the genome of human. |
Short Label | hPROC |
Category | organism-gene |
P04070 (PROC) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T19 | O-Glycosylation | score2 | GlyGen UniProt | 22171320 | ||
N139 | N-Glycosylation | score3 | GlyGen | 29741879, 19343721, 25326145 | ||
K233 | Acetylation | score1 | PhosphoSitePlus | |||
K234 | Acetylation | score1 | PhosphoSitePlus | |||
N290 | N-Glycosylation | score4 | GlyGen UniProt | 16335952, 34725484, 19343721, ... | ||
S347 | Phosphorylation | score1 | UniProt | 26091039 | ||
N355 | N-Glycosylation | score4 | GlyGen UniProt | 19343721, 2991887 | ||
N371 | N-Glycosylation | score4 | GlyGen UniProt | 19343721, 1694179, 8130392, ... | ||
S382 | O-Glycosylation | score1 | GlyGen | 30459171 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K233 | N233 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
S347 | N347 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S347 | R347 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S382 | Y382 | Biomuta | DOID:4159 / skin cancer [ cosmic ] |