iPTMnet Report for P04062 (GBA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P04062 / GBA1_HUMAN
Protein Name Lysosomal acid glucosylceramidase precursor
Gene Name Name: GBA1
Synonyms:GBA,GC,GLUC;
Organism Homo sapiens (Human)

PRO ID PR:P04062
DAG View
PRO Name lysosomal acid glucosylceramidase (human)
Definition A lysosomal acid glucosylceramidase that is encoded in the genome of human.
Short Label hGBA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P04062 (GBA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N58 N-Glycosylation GlyGen   UniProt 29741879, 12792654, 17139081
N98 N-Glycosylation GlyGen   UniProt 29741879, 12754519, 17139081, ...19159218, 24190977
K118 Ubiquitination PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
N185 N-Glycosylation GlyGen   UniProt 29741879, 12754519, 17139081, ...32125861, 24190977
S187 O-Glycosylation GlyGen 34019948, 34725712, 30059200, ...35254053
K194 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
Y244 Phosphorylation PhosphoSitePlus
N309 N-Glycosylation GlyGen   UniProt 29741879, 12754519, 19159218, ...32125861, 24190977
S310 O-Glycosylation GlyGen 34019948, 34725712, 30059200, ...35254053
K332 Ubiquitination PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
Y412 Phosphorylation PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S136 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S187 C187 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
N309 S309 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T336 I336 Biomuta DOID:9256 / colorectal cancer [ cosmic ]