iPTMnet Report for P02649 (APOE)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P02649 / APOE_HUMAN
Protein Name Apolipoprotein E precursor
Gene Name Name: APOE
Organism Homo sapiens (Human)

PRO ID PR:P02649
DAG View
PRO Name apolipoprotein E (human)
Definition An apolipoprotein E that is encoded in the genome of human.
Short Label hAPOE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P02649 (APOE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T26 O-Glycosylation GlyGen   UniProt 23234360
T26 Phosphorylation PhosphoSitePlus
T36 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23584533, 30459171, 23234360
T101 Phosphorylation PhosphoSitePlus
S147 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19824718, 26091039, 20166139, ...24275569
K175 Acetylation PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
T212 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 2498325, 30459171, 25813380, ...23234360, 19838169, 23584533
T212 Phosphorylation PhosphoSitePlus
S215 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171
S215 Phosphorylation PhosphoSitePlus
S241 Phosphorylation HPRD   PhosphoSitePlus 20068231
K260 Acetylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
T307 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23584533, 30459171, 19838169
S308 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 20511397, 30459171, 23234360, ...19838169, 23584533
S314 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23584533, 23234360
S314 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 15882073


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S147 N147 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S241 G241 Biomuta DOID:263 / kidney cancer [ icgc ]