iPTMnet Report for P02647 (APOA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P02647 / APOA1_HUMAN
Protein Name Apolipoprotein A-I precursor
Gene Name Name: APOA1
Organism Homo sapiens (Human)

PRO ID PR:P02647
DAG View
PRO Name apolipoprotein A-I (human)
Definition An apolipoprotein A-I that is encoded in the genome of human.
Short Label hAPOA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P02647 (APOA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y53 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus   RLIMS-P 19945452
S60 Phosphorylation PhosphoSitePlus
K130 Acetylation PhosphoSitePlus
K131 Acetylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K157 Acetylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus   RLIMS-P 19945452
T185 Phosphorylation PhosphoSitePlus   RLIMS-P 19945452
Y190 Phosphorylation PhosphoSitePlus
S191 Phosphorylation HPRD   PhosphoSitePlus 19824718
Y216 Phosphorylation PhosphoSitePlus
K219 Acetylation PhosphoSitePlus
T221 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T221 Phosphorylation PhosphoSitePlus   RLIMS-P 19945452
S225 Phosphorylation PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
S228 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S252 Phosphorylation PhosphoSitePlus   RLIMS-P 19945452
K262 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S60 F60 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
T226 K226 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]