iPTMnet Report for P02489 (CRYAA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P02489 / CRYAA_HUMAN
Protein Name Alpha-crystallin A chain
Gene Name Name: CRYAA
Synonyms:CRYA1,HSPB4;
Organism Homo sapiens (Human)

PRO ID PR:P02489
DAG View
PRO Name alpha-crystallin A chain (human)
Definition An alpha-crystallin A chain that is encoded in the genome of human.
Short Label hCRYAA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P02489 (CRYAA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 817940
T13 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 12060738
Y18 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
R21 Methylation PhosphoSitePlus
S45 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 12060738, 9068373
Y48 Phosphorylation PhosphoSitePlus
K70 Acetylation PhosphoSitePlus   UniProt 22120592, 9655350
K78 Acetylation PhosphoSitePlus
K88 Acetylation PhosphoSitePlus
K88 Methylation PhosphoSitePlus
K99 Acetylation PhosphoSitePlus   UniProt 22120592
S122 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 12060738, 8175657, 8759518, ...9068373
T140 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 12060738
K145 Acetylation PhosphoSitePlus
T148 Phosphorylation PhosphoSitePlus   RLIMS-P 34071438
S162 O-Glycosylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y18 H18 Biomuta DOID:4159 / skin cancer [ cosmic ]
R21 W21 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R21 Q21 Biomuta DOID:363 / uterine cancer [ icgc ]
T140 I140 Biomuta DOID:9256 / colorectal cancer [ cosmic ]