iPTMnet Report for P02489 (CRYAA)
Protein Information
UniProt AC / UniProt ID | P02489 / CRYAA_HUMAN |
Protein Name | Alpha-crystallin A chain |
Gene Name | Name: CRYAA Synonyms:CRYA1,HSPB4; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P02489 |
PRO Name | alpha-crystallin A chain (human) |
Definition | An alpha-crystallin A chain that is encoded in the genome of human. |
Short Label | hCRYAA |
Category | organism-gene |
P02489 (CRYAA) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
M1 | Acetylation | score2 | UniProt | 817940 | ||
T13 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 12060738 | ||
Y18 | Phosphorylation | score1 | PhosphoSitePlus | |||
S20 | Phosphorylation | score1 | PhosphoSitePlus | |||
R21 | Methylation | score1 | PhosphoSitePlus | |||
S45 | Phosphorylation | score4 | HPRD phospho.ELM PhosphoSitePlus UniProt | 12060738, 9068373 | ||
Y48 | Phosphorylation | score1 | PhosphoSitePlus | |||
K70 | Acetylation | score4 | PhosphoSitePlus UniProt | 22120592, 9655350 | ||
K78 | Acetylation | score1 | PhosphoSitePlus | |||
K88 | Acetylation | score1 | PhosphoSitePlus | |||
K88 | Methylation | score1 | PhosphoSitePlus | |||
K99 | Acetylation | score3 | PhosphoSitePlus UniProt | 22120592 | ||
S122 | Phosphorylation | score4 | HPRD phospho.ELM PhosphoSitePlus UniProt | 12060738, 8175657, 8759518, ... | ||
T140 | Phosphorylation | score3 | HPRD phospho.ELM PhosphoSitePlus | 12060738 | ||
K145 | Acetylation | score1 | PhosphoSitePlus | |||
T148 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 34071438 | ||
S162 | O-Glycosylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y18 | H18 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
R21 | W21 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R21 | Q21 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
T140 | I140 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |