iPTMnet Report for P01116 (KRAS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P01116 / RASK_HUMAN
Protein Name GTPase KRas precursor
Gene Name Name: KRAS
Synonyms:KRAS2,RASK2;
Organism Homo sapiens (Human)

PRO ID PR:P01116
DAG View
PRO Name GTPase KRas (human)
Definition A GTPase KRas that is encoded in the genome of human.
Short Label hKRAS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P01116 (KRAS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation PhosphoSitePlus
Y4 Phosphorylation PhosphoSitePlus
K5 Methylation PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus   RLIMS-P 30644389
T35 O-Glycosylation UniProt 19744486
S39 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
K42 Sumoylation PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus   RLIMS-P 30644389, 33680360
S89 Phosphorylation PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
K101 Acetylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus   UniProt 22711838
K104 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
K147 Acetylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
T148 Phosphorylation PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
K170 Ubiquitination UniProt 30442762
Site PTM Type PTM Enzyme Score Source PMID
K104 Acetylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
T148 Phosphorylation PhosphoSitePlus
Y157 Phosphorylation PhosphoSitePlus
T158 Phosphorylation PhosphoSitePlus
K179 Acetylation PhosphoSitePlus
S181 Phosphorylation Q04759 (PRKCQ) , P17252 (PRKCA) PhosphoSitePlus 16483930, 20802526
K182 Methylation PhosphoSitePlus
K184 Methylation PhosphoSitePlus
C185 Farnesylation IntAct 23698361


P01116 (KRAS) as PTM Enzyme



Substrate Site Score Source PMID
Q13233 (MAP3K1) S67 Signor 12228228, 8649450


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P01116 (KRAS) Y64 Q9Y6X8 (ZHX2) decreased_association eFIP 30644389
Phosphorylation P01116 (KRAS) Y64 Q9H1B5 (XYLT2) unknown eFIP 33680360


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T2 I2 Biomuta DOID:4159 / skin cancer [ cosmic ]
K5 N5 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K5 E5 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K5 R5 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T35 A35 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T35 I35 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S39 Y39 Biomuta DOID:4362 / cervical cancer [ cosmic ]
Y64 D64 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
Y64 H64 Biomuta DOID:4362 / cervical cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y64 N64 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S89 * Biomuta DOID:363 / uterine cancer [ cosmic, cosmic ] DOID:9256 / colorectal cancer [ cosmic, cosmic, cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
K104 N104 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K117 R117 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K117 E117 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K117 N117 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc, tcga ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:3119 / gastrointestinal system cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T144 P144 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K147 E147 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ]
K147 N147 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K147 T147 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y157 C157 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
K170 Q170 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K170 N170 Biomuta DOID:3571 / liver cancer [ cosmic ]
S181 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S181 P181 Biomuta DOID:363 / uterine cancer [ cosmic ]
K182 E182 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
C185 R185 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
C185 S185 Biomuta DOID:1324 / lung cancer [ cosmic ]