iPTMnet Report for P00918 (CA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00918 / CAH2_HUMAN
Protein Name Carbonic anhydrase 2
Gene Name Name: CA2
Organism Homo sapiens (Human)

PRO ID PR:P00918
DAG View
PRO Name carbonic anhydrase 2 (human)
Definition A vertebrate-type carbonic anhydrase 2 that is encoded in the genome of human.
Short Label hCA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00918 (CA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 4207120, 823150
S2 Phosphorylation PhosphoSitePlus
K18 Acetylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
K39 Acetylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
Y51 Phosphorylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus
Y114 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus   UniProt 24275569
S172 Phosphorylation PhosphoSitePlus   UniProt 24275569
S216 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K18 N18 Biomuta DOID:1324 / lung cancer [ cosmic ]
K18 T18 Biomuta DOID:1319 / brain cancer [ cosmic ]
K39 N39 Biomuta DOID:1324 / lung cancer [ cosmic ]
K45 E45 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S48 Y48 Biomuta DOID:363 / uterine cancer [ icgc ]
S48 C48 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y51 C51 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K80 N80 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:2021 / placenta cancer [ cosmic ]
S151 I151 Biomuta DOID:363 / uterine cancer [ icgc ]
S165 F165 Biomuta DOID:4159 / skin cancer [ cosmic ]