iPTMnet Report for P00748 (F12)
Protein Information
UniProt AC / UniProt ID | P00748 / FA12_HUMAN |
Protein Name | Coagulation factor XII precursor |
Gene Name | Name: F12 |
Organism | Homo sapiens (Human) |
PRO ID | PR:P00748 |
PRO Name | coagulation factor XII (human) |
Definition | A coagulation factor XII that is encoded in the genome of human. |
Short Label | hF12 |
Category | organism-gene |
P00748 (F12) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y31 | Phosphorylation | score1 | PhosphoSitePlus | |||
T43 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
Y53 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y58 | Phosphorylation | score1 | PhosphoSitePlus | |||
T109 | O-Glycosylation | score3 | GlyGen UniProt | 1544894 | ||
N181 | N-Glycosylation | score1 | GlyGen | 29391424 | ||
S243 | Phosphorylation | score1 | PhosphoSitePlus | |||
N249 | N-Glycosylation | score4 | GlyGen UniProt | 16335952, 23090970, 3877053, ... | ||
T299 | O-Glycosylation | score4 | GlyGen UniProt | 30459171, 3886654 | ||
T305 | O-Glycosylation | score3 | GlyGen UniProt | 3886654 | ||
S308 | O-Glycosylation | score3 | GlyGen UniProt | 3886654 | ||
T328 | O-Glycosylation | score4 | GlyGen UniProt | 30459171, 3886654 | ||
T329 | O-Glycosylation | score3 | GlyGen UniProt | 3886654 | ||
T331 | Phosphorylation | score1 | PhosphoSitePlus | |||
S335 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
T337 | O-Glycosylation | score4 | GlyGen UniProt | 30459171, 3886654 | ||
S366 | Phosphorylation | score1 | PhosphoSitePlus | |||
S368 | Phosphorylation | score1 | PhosphoSitePlus | |||
T371 | Phosphorylation | score1 | PhosphoSitePlus | |||
N433 | N-Glycosylation | score2 | GlyGen UniProt | 16335952, 23090970, 14760718, ... | ||
R466 | Methylation | score1 | PhosphoSitePlus | |||
C486 | Methylation | score1 | IEDB | 31844290 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T43 | A43 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
T305 | P305 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
T328 | M328 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
R466 | S466 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |