iPTMnet Report for P00734 (F2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00734 / THRB_HUMAN
Protein Name Prothrombin precursor
Gene Name Name: F2
Organism Homo sapiens (Human)

PRO ID PR:P00734
DAG View
PRO Name prothrombin (human)
Definition A prothrombin that is encoded in the genome of human.
Short Label hF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00734 (F2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T78 O-Glycosylation GlyGen 30459171
N121 N-Glycosylation GlyGen   UniProt 16335952, 7309709, 30237853, ...23090970, 14760718, 29391424, 24841998, 22171320, 29671580
N143 N-Glycosylation GlyGen   UniProt 16335952, 34725484, 24530628, ...7309709, 30237853, 23090970, 14760718, 22171320, 24279413, 29391424, 29741879, 29671580, 29992770
T145 O-Glycosylation GlyGen 30459171
T192 O-Glycosylation GlyGen 30459171
S199 Phosphorylation PhosphoSitePlus
S207 O-Glycosylation GlyGen 30459171
N260 N-Glycosylation GlyGen 29391424
T315 O-Glycosylation GlyGen 30459171
T317 O-Glycosylation GlyGen 30459171
Y320 Phosphorylation PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
C336 Methylation IEDB 31844290
N416 N-Glycosylation GlyGen   UniProt 16335952, 7309709, 32125861, ...19159218, 24190977, 23090970, 29391424, 19139490, 19838169, 873923, 29741879, 24279413, 29671580
Y434 Phosphorylation PhosphoSitePlus
S539 Phosphorylation HPRD   PhosphoSitePlus 20068231
T540 Phosphorylation HPRD   PhosphoSitePlus 20068231
K599 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N121 N-Glycosylation PRO 29671580, 24841998, 7309709, ...22171320
N143 N-Glycosylation PRO 24279413, 29671580, 22171320, ...7309709
N416 N-Glycosylation PRO 24279413, 19838169, 29671580, ...7309709


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S199 F199 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
N260 Y260 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S331 * Biomuta DOID:1324 / lung cancer [ cosmic ]