iPTMnet Report for P00568 (AK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00568 / KAD1_HUMAN
Protein Name Adenylate kinase isoenzyme 1
Gene Name Name: AK1
Organism Homo sapiens (Human)

PRO ID PR:P00568
DAG View
PRO Name adenylate kinase isoenzyme 1 (human)
Definition An adenylate kinase isoenzyme 1 that is encoded in the genome of human.
Short Label hAK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00568 (AK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO   UniProt 183954
S19 Phosphorylation PhosphoSitePlus
K21 Acetylation PhosphoSitePlus
C25 S-Nitrosylation dbSNO 24105792
K27 Ubiquitination PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T71 Phosphorylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
R107 Methylation PhosphoSitePlus
T145 Phosphorylation PhosphoSitePlus
Y153 Phosphorylation HPRD 20068231
K166 Ubiquitination PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
C187 S-Nitrosylation dbSNO 24105792


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036202 (hAK1/Ac:1) acM1 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T35 S35 Biomuta DOID:1324 / lung cancer [ cosmic ]
K166 I166 Biomuta DOID:3571 / liver cancer [ cosmic ]
S178 F178 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C187 Y187 Biomuta DOID:4159 / skin cancer [ cosmic ]