iPTMnet Report for P00491 (PNP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P00491 / PNPH_HUMAN
Protein Name Purine nucleoside phosphorylase
Gene Name Name: PNP
Synonyms:NP;
Organism Homo sapiens (Human)

PRO ID PR:P00491
DAG View
PRO Name purine nucleoside phosphorylase (human)
Definition A purine nucleoside phosphorylase that is encoded in the genome of human.
Short Label hPNP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P00491 (PNP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO   UniProt 19413330, 22223895
K11 Ubiquitination PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
K41 Acetylation PhosphoSitePlus
K95 Acetylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
R168 Methylation PhosphoSitePlus
T169 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
T177 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
C206 Methylation IEDB 31844290
K211 Acetylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
Y249 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus   UniProt 23186163
K254 Acetylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036327 (hPNP/Ac:1) acM1 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K95 M95 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R168 W168 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T169 D169 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S176 T176 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T177 A177 Biomuta DOID:10534 / stomach cancer [ cosmic ]