iPTMnet Report for P00441 (SOD1)
Protein Information
| UniProt AC / UniProt ID | P00441 / SODC_HUMAN |
| Protein Name | Superoxide dismutase [Cu-Zn] |
| Gene Name | Name: SOD1 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P00441 |
| PRO Name | superoxide dismutase [Cu-Zn] (human) |
| Definition | A superoxide dismutase [Cu-Zn] that is encoded in the genome of human. |
| Short Label | hSOD1 |
| Category | organism-gene |
P00441 (SOD1) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| A2 | Acetylation | score3 | UniProt | 1463506, 25944712, 7002610 | ||
| T3 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K4 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C7 | Methylation | score1 | IEDB | 31844290 | ||
| C7 | S-Nitrosylation | score0 | dbSNO | 19483679, 24105792, 25040305 | ||
| K10 | Acetylation | score1 | PhosphoSitePlus | |||
| K10 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K24 | Acetylation | score1 | PhosphoSitePlus | |||
| K24 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S26 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K31 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S35 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K37 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T40 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T59 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S60 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 24647101 | ||
| S69 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K71 | Acetylation | score1 | PhosphoSitePlus | |||
| K71 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K76 | Sumoylation | score1 | PhosphoSitePlus | |||
| K76 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R80 | Methylation | score1 | PhosphoSitePlus | |||
| N87 | N-Glycosylation | score1 | GlyGen | 29741879 | ||
| T89 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K92 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S99 | Phosphorylation | score4 | HPRD PhosphoSitePlus RLIMS-P UniProt | 24647101, 18669648, 24275569, ... | ||
| S103 | Phosphorylation | score2 | HPRD PhosphoSitePlus UniProt | 24275569, 20230923 | ||
| S106 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S108 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K123 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K123 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K129 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K137 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R144 | Methylation | score1 | PhosphoSitePlus | |||
| C147 | Methylation | score1 | IEDB | 31844290 | ||
| C147 | S-Nitrosylation | score0 | dbSNO | 26338901 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| A2 | V2 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| T3 | M3 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| K4 | R4 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| K10 | R10 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S35 | R35 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
| K37 | Q37 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] | |
| K37 | T37 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| R80 | M80 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S103 | F103 | Biomuta | DOID:363 / uterine cancer [ icgc ] |
DAG View