iPTMnet Report for P00439 (PAH)
Protein Information
| UniProt AC / UniProt ID | P00439 / PH4H_HUMAN |
| Protein Name | Phenylalanine-4-hydroxylase |
| Gene Name | Name: PAH |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P00439 |
| PRO Name | phenylalanine-4-hydroxylase (human) |
| Definition | A phenylalanine-4-hydroxylase that is encoded in the genome of human. |
| Short Label | hPAH |
| Category | organism-gene |
DAG ViewP00439 (PAH) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T3 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S16 | Phosphorylation | P17612 (PRKACA) | score4 | IEDB phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 20937381, 8573072, 2451499, ... | |
| S87 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T92 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T117 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C265 | Methylation | score1 | IEDB | 31844290 | ||
| S436 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C445 | Methylation | score1 | IEDB | 31844290 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S16 | F16 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] | |
| S16 | Y16 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| C265 | F265 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S436 | Y436 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S436 | F436 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| C445 | F445 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] |
